Genome-wide association studies genomics

Price, A.L., Patterson, N.J., Plenge, R.M., Weinblatt, M.E., Shadick, N.A., and Reich, D. (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 38, 904-909. Available at http //genepath.med.Harvard.edu/ reich/ EIGENSTRAT.htm. 

Wiltshire S, de Bakker PI, Daly MJ. (2006) The value of gene-based selection of tag SNPs in genome-wide association studies. EurJ Hum Genet. 14,1209-1214. 

Hirschhorn JN, Daly MJ. (2005) Genome-wide association studies for common diseases and complex traits. Nat Rev Genet. 6, 95-108. 

Saito A, Kamatani N. (2002) Strategies for genome-wide association studies optimization of study designs by the stepwise focusing method. J Hum Genet. 47,360-365. 

Ohnishi Y, Tanaka T, Ozaki K, YamadaR, Suzuki H, Nakamura Y. (2001) A high-throughput SNP typing system for genome-wide association studies. J Hum Genet. 46,471-477. 

Barrett JC, Cardon LR. (2006) Evaluating coverage of genome-wide association studies. Nat Genet. 38, 659-662. 

Yang Q, Cui J, Chazaro I, Guppies LA, Demissie S. (2005) Power and type I error rate of false discovery rate approaches in genome-wide association studies. BMC Genet. 6(suppl 1), SI34. 

Smyth DJ, Cooper JD, Bailey R et al. A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIHl) region. Nat Genet 2006 38 617-619. 

Many of the genes that increase vulnerability to bipolar disorder are common to schizophrenia but some genes appear to be unique to each disorder. Genome-wide association studies of psychotic bipolar disorder have shown replicated linkage to chromosomes 8p and 13q. Several candidate genes have shown association with bipolar disorder with psychotic features and with schizophrenia. These include genes for dysbindin, DAOA/G30, disrupted-in-schizophrenia-1 (DISC-1), and neuregulin 1. 

Genome-Wide Association Studies and Haplotype Blocks... 

Lin S, Chakravarti A, Cutler DJ. 2004. Exhaustive allelic transmission disequilibrium tests as a new approach to genome-wide association studies. Nat Genet 36 1181-1188. 

Craddock N, O Donovan MC, Owen MJ. 2008. Genome-wide association studies in psychiatry Lessons from early studies of non-psychiatric and psychiatric phenotypes. Mol Psychiatry 13 649-653. 

DeYoung J, Karayiorgou M, Roos JL, Pretorious H, Bedoya G, et al. 2006. Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies. Nat Genet 38(5) 556-560. 

McCarthy MI, Hirschhorn JN (2008) Genome-wide association studies potential next steps on a genetic journey. Hum Mol Genet 17 R156-R165... 

Previous studies showed that a cluster of missense polymorphisms located in the cytoplasmic tail of the CASR is associated with interindividual population differences in [Ca2+]o [43], Different haplotypes are associated with primary hyperparathyroidism and the frequency of kidney stones [44], More recent genome-wide association studies in -33,000 individuals of European and Indian Asian ancestry confirmed that the blood calcium concentration associated most significandy with SNPs in the CASR gene [45, 46],... 

Hall FS, Drgonova J, Jain S, Uhl GR (2013) Implications of genome wide association studies for addiction are our a priori assumptions all wrong Pharmacol Ther. doi 10.1016/j. pharmthera. 2013.07.006... 

Nishizawa D, Fukuda K, Kasai S et al (2012) Genome-wide association study identifies a potent locus associated with human opioid sensitivity. Mol Psychiatry. doi 10.1038/ mp.2012.164... 

Mathias RA, Grant AV, Rafeels N et al (2009) A genome-wide association study on African-ancestry populations for asthma. J Allergy Clin Immunol 125 336-346... 

Lane J, McLaren PJ, Dorrell L et al (2013) A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A. Hum Mol Genet 22 1903-1910... 

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