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Fig. 7.4. Phylogenetic analysis of the ADP/ATP carriers (AACs) has so far revealed that only the hydrogenosomes of chytrids and ciliates possess genuine mitochondrial AACs, which cluster with the mitochondrial homologues of their aerobic, mitochondria-bearing relatives (2, 3) (Voncken 2001 Voncken et al. 2002a van der Giezen et al. 2002 Tjaden et al. 2004). The AAC of the mitochondrial remnant of Cryptosporidium clusters with the mitochondrial transporters of the distantly related Plasmodium (the closest relative from which a complete genome DNA sequence is available) (1). Trichomonas (5) and Entamoeba (4) use alternative members of the mitochondrial carrier family for the transport of ATP across the hydrogenosomal/mitosomal membranes (Dyall et al. 2000 Tjaden et al. 2004 Chan et al. 2005 Tjaden and Leroch, unpublished results)...

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