Plasmodium falciparum genome

Gunasekera AM, Myrick A, Le Roch K et al (2007) Plasmodium falciparum genome wide perturbations in transcript profiles among mixed stage cultures after chloroquine treatment. Exp Parasitol 117 87-92... 

Gardner, M. J. et al. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 2002, 419, 498-511. 

Gardner M), Tettelin H, Carucci DJ et al. Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Science 1998 282[5391] 1126 1132. Hoffman SL, Rogers WO, Carucci DJ, Venter JC. From genomics to vaccines malaria as a model system. Nature Med 1998 4[12] 1351—1353. 

Painter HJ, Morrisey JM, Mather MW, Vaidya AB (2007) Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum. Nature 446 88-91 Pisani D, Cotton JA, Mclnerney JO (2007) Supertrees disentangle the chimaeric origin of eukaryote genomes. Mol Biol Evol 24 1752-1760 Poulton SW, Fralick PW, Canfield DE (2004) The transition to a sulphidic ocean 1.84 billion years ago. Nature 431 173-177... 

Yeh I, Hanekamp T, Tsoka S et al (2004) Computational analysis of Plasmodium falciparum metabolism organizing genomic information to facilitate drug discovery. Genome Res 14 917-924... 

Plasmodium falciparum the kinome of a divergent eukaryote. BMC Genomics 5 79... 

Schneider AG, Mercereau-Puijalon O (2005) A new Apicomplexa-specific protein kinase family multiple members in Plasmodium falciparum, all with an export signature. BMC Genomics 6 30... 

Vedadi M, Lew J, Artz J et al (2007) Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms. Mol Biochem Parasitol 151(1) 100-110... 

Artemisinin is used here as an example of a plant sesquiterpenoid with both traditional value as well as with medicinal and social value in the twenty-first century. Research on artemisinin has also established new benchmarks for biochemical engineering and functional genomics of plant terpenoids. Artemisinin is a functionalized sesquiterpene with a unique peroxide linkage from the sweet wormwood Artemisia annua). Chinese herbalists have used it since ancient times, and it is now used for its unique efficacy to treat multidrug-resistant strains of the malaria parasite Plasmodium falciparum. Its medicinal importance has prompted studies into its biosynthesis and its biochemical engineering so that cost-effective methods for producing it in large scale and in consistent quality may be realized. 

Mitochondria are semiautonomous organelles that live in an endosymbiotic relation with the host cell. These organelles contain their own DNA, which encodes a variety of different proteins and RNAs. The genomes of mitochondrial range broadly in size across species. The mitochondrial genome of the protist Plasmodium falciparum consists of fewer than 6000 base pairs (6 kbp), whereas those of some land plants comprise more than 200 kbp (Figure... 

GeneSplicer [78] detects splice sites in the genomic DNA of Plasmodium falciparum (malaria), Arabidopsis thaliana, human, Drosophila, and rice. 

Gardner, M. J., N. Hall, E. Fung, O. White, M. Berriman, R. W. Hyman, J. M. Carlton, et al. 2002. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419 498-511. 

Date, S. V. and C. J. Stoeckert. 2006. Computational modeling of the Plasmodium falciparum interactome reveals protein function on a genome-wide scale. Genome Res. 16, 542-549. 

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