Drugs defined

Morganroth, J. (2007) Cardiac repolarization and the safety of new drugs defined by electrocardiography. Clinical Pharmacology and Therapeutics, 81, 108-113. 

The study we focus on here involved surveys similarly constructed and administered at seven sites to over 27,000 individuals ages 14-54 years (Vega et al., 2002). The emphasis of this report was lifetime use of alcohol, defined as used at least 12 times, and lifetime use of other drugs, defined as used at least 5 times. The seven countries/cities where surveys were conducted w cre the United States Fresno County, California (United States) Mexico City, Mexico Ontario, Canada the Netherlands Sao Paulo, Brazil and Munich, Germany. 

Part III deals with the administration of the law regarding controlled drugs. A controlled drug is defined as a drug listed in Schedule G of the Act. Punishments for trafficking or other violations of Part III can be up to ten years imprisonment. Part IV discusses restricted drugs, defined as listed in Schedule H of the Act. 

A MA for a herbal medicinal product may be submitted, as for any medicinal product, through a full application with new tests and trials, whenever the application refers to a new product or a therapeutic innovation. Alternatively, for a well-established drug (defined in Directive 99/83) a bibliographic application may be submitted, when safety and efficacy for a given indication, dose and patient population are satisfactorily described in the published literature. 

Physical dependence—(1) A state of adaptation that is manifested by a drug class specific withdrawal syndrome that can be produced by abrupt cessation, rapid dose reduction, decreasing blood level of the drug, and/or administration of an antagonist. (2) A pharmacologic effect of a drug defined by the occurrence of an abstinence syndrome... 

Stearns, T., M. A. Hoyt, and D. Botstein (1990). Yeast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function. Genetics 124, 251-262. 

Small molecule drugs, defined as drngs with typical molecular weights <500 daltons, have been the main drivers of sales growth for Big Pharma. The projections lean toward a change in this trend by the turn of this decade. The pharmacentical industry is expected to move rapidly toward biologic products, defined nsnally, bnt not exclnsively, as protein-based therapentic agents. Therapentic... 

The pharmacokinetic performance of a drug influences the construction of a formulation. This has nowadays led to a dominance of drug delivery systems that provide a controlled or modified release of the drugs, defined as extended or delayed release. Release-controlling polymers are used to build up a barrier that prevents immediate release of a compound. In this way high peak plasma concentrations of drugs are avoided and usually only one dose per day is necessary. The characteristic properties of the formula are evaluated in in vivo tests where blood samples are analyzed often by extremely sensitive bioanalytical methods. 

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