Genetic variance

Rumbaugh, M.D., Asay, K.H. Johnson, D.A. (1984). Influence of drought stress on genetic variances of alfalfa and wheatgrass seedlings. Crop Science, 24, 297-302. 

While tau mutations have provided an important piece in the puzzle of FTD genetics, they probably account for less than 50% of the genetic variance in familial FTD [64]. However, the successful identification of additional contributing genetic factors largely depends on the development of precise phenotypic classification schemes, which... 

A factor analysis of the results yielded 39 first-order and 11 second order factors. The mean intraclass correlations for the three groups of twins are shown in Table 2. The heritability estimate for the 50 factors is highly consistent across methods the MZA direct estimate is (.42) and the estimate based on reared together twins is. 52. In this instance we found evidence for non additive genetic variance for only a few measures. 

The results of this study strongly confirm our initial findings of nonadditive genetic variance for psychological interests. 

Knoblauch, H., Bauerfeind, A., Toliat, M.R., et al. (2004) Haplotypes and SNPs in 13 hpid-relevant genes explain most of the genetic variance in high-density lipoprotein and low-density lipoprotein cholesterol. Hum. Mol. Genet., 13, 993-1004. 

H.H. (1998) Environmental and genetic variance in children s observed and reported maladaptive behavior. Child Dev 69(5) 1286-98. 

Petfleld, D., Chenoweth, S.F., Rundle, H.D. and Blows, M. W. (2005). Genetic variance in female condition predicts indirect genetic variance in male sexual display traits. Proc. Natl. Acad. Sci. USA, 102, 6045-6050. 

Figueroa KP, Farooqi S, Harrup K, Frank J, O Rahilly S, Pulst SM (2009) Genetic variance in the spinocerebellar ataxia type 2 (ATXN2) gene in children with severe early onset obesity. PLoS... 

A medication error is any preventable event that may cause or lead to inappropriate medication use or patient harm while medication is in the control of a healthcare professional/ patient/ or consumer (6). Not all medication errors reach the patient. These are often referred to as "near misses." They are not usually considered to be ADEs only because no harm was done. Preventable ADEs are a subset of medication errors that cause harm to a patient (7). Figure 26.1 depicts the relationship between ADES/ medication errorS/ and adverse drug reactions (8). Because adverse drug reactions are generally unexpected/ they are not presently considered to be a reflection of medication use quality in a classic sense. However/ as genetic variances become a more prominent consideration in drug selection and monitoring/ it may be possible to predict and avoid some of the reactions that have been previously unexpected. This offers an opportunity to improve the quality of medication use. 

Ganges tad It seems that one of David Houle s points is that the factors that give rise to the genetic variance in may have little to do with the brain mechanisms that underlie the cognitive abilities that are captured by. For instance, it s possible that mutations across the whole genome contribute to that variation, but contribute to variation in lots of other traits as well. The genes may have little to do with the actual brain mechanisms. 

Maynard Smith I am suggesting that most of the genetic variance is due to deleterious mutation. This is probably true why wouldn t it be like that ... 

Fisher s Fundamental Theorem and the assumption of no perturbations suggest that there should be no variance in fitness. This assertion is difficult to test directly. Burt (1995) reviewed 13 estimates of the variance in fitness in six different species, and only two were significant. Because one cannot prove absence, the meaning of this result is unclear. Of course many examples of directional changes in populations suggest that variance in fitness is often present (Endler 1986). Experimenters have usually had to content themselves with measuring fitness components, and these very often display substantial genetic variance (Houle 1992, Mousseau Roff 1987, Roff Mousseau 1987). Two interpretations of this result are possible, and are most easily introduced with a simple model (Houle 1991). 

The essence of the cruel-world scenario is that natural selection is continually pursuing an elusive optimum that the population is being pushed away from. The result is genetic variance in fitness and positive correlations among fitness components, that is, the existence of an f factor. 

Houle D 1998 How should we explain variation in the genetic variance of traits Genetica 102/ 103 241-253... 

Promislow DEL, Tatar M, Khazaeli AA, Curtsinger JW 1996 Age-specific patterns of genetic variance in Drosophila melanogaster. I. Mortality. Genetics 143 839-848 Roff DA 1996 The evolution of genetic correlations an analysis of patterns. Evolution 50 1392— 1403... 

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