Genetic predispositions schizophrenia

Other research has studied how childhood experiences may contribute to the development of a Cluster A personality disorder. Psychosocial explanations revolve around the observation that there is a degree to which distrust is a rational response to certain experiences. Some have theorized that cold and indifferent parenting can contribute to the disinterest in relationships that characterizes Cluster A disorders. It is in fact likely that a genetic predisposition to subclinical personality traits that mirror the positive and/or negative symptoms of schizophrenia may combine with certain developmental experiences that conspire to the development of a Cluster A personality disorder. 

If DMT and 5-methoxy-DMT are neurotransmitters, as many researchers think, then an excess of them may be a cause of schizophrenia. Observing dramatic increases of DMT in the spinal fluid of animals and humans "during extreme stress," Dr. Christian hypothesized that the tendency among some people to develop mental aberrations might reflect "a genetic predisposition to excessive DMT production as a response to stress. Later work, reported by L. Corbett, Christian and others in the British Journal of Psychiatry (1978, 132 139-144), indicated that schizophrenics do not have higher levels of DMT in their brains than control subjects. Research in this intriguing area continues. 

Schizophrenia has been attributed to everything from genetic predisposition, brain chemistry, sufferers home environment and even cat-borne viruses, but no consistent causal pattern has ever been identified. 

Since the cannabinoid agonists are not first-line drugs in the treatment of any of the various types of pain or pain syndromes, any potential risk of serious consequences from their use should be considered an absolute contraindication. Preexisting or genetic predisposition to serious psychiatric disorders such as schizophrenia or psychotic disorders, in general, would be an example. Precipitation or worsening of these and less serious psychiatric disorders has been reported. Caution and close monitoring of patients with less serious illnesses such as bipolar disorder, anxiety, or depression is necessary since the symptoms of these disorders could become manifest. 

Rutter The predictive power comes from both IQ and developmental delays, way before the onset of schizophrenia. It seems likely to be involved in the predisposition in some sort of way, but whether that is genetic or due to environmental hazards is still a matter of debate. There is also debate as to whether this is diagnosis-specific or not. For quite a long time people saw this as an early marker of a genetic liability to schizophrenia. But the fact that similar, although weaker associations have been found for bipolar disorder throws that in question. 

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