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Genetic immunotherapy

Methods Used to Identify Specific Tumor Antigens for Use in Lung Cancer Genetic Immunotherapy... [Pg.246]

Heike Y, Takahashi M, Ohira T, et al. Genetic immunotherapy by intrapleural, intraperitoneal and subcutaneous injection of IL-2 gene-modified lewis lung carcinoma cells. Int J Cancer 1997 73 844-849. [Pg.275]

Lee C-T, Wu S, CiemikF, etal. Genetic immunotherapy of established tumors with adenovims-murine granulocyte-macrophage colony-stimiilaling factor. Hum Gene Ther 1997 8 187-193. [Pg.280]

While on the one hand the aspects of Tregs and tolerance induction in allergen-specific immunotherapy and different procedures of vaccination are described, one chapter is added which describes future possibilities of stem cell transplantation in genetically linked disorders. [Pg.242]

Bronte, V, Genetic vaccination for the active immunotherapy of cancer. Curr Gene Ther, 2001.1(1) 53-100. [Pg.326]

Wilcock DM, Colton CA (2008) Anti-amyloid-beta immunotherapy in Alzheimer s disease relevance of transgenic mouse studies to clinical trials. J Alzheimers Dis 15 555-569 Wilhamson J, LaRusse S (2004) Genetics and genetic counseling recommendations for Alzheimer s disease, frontotemporal dementia, and Creutzfeldt-Jakob disease. Curr Neurol... [Pg.630]

Discovery of Target Molecules for Cancer Immunotherapy by Genetic and Bioinformatic Approaches... [Pg.343]

Dnrg discovery encompasses the identification of molecular- structures, the creation of active molecules, and the development of novel comprehensive therapies like immunotherapy and cellular or organismal therapy with genetically engineered cells. [Pg.4]

Cancer immunotherapy by genetically engineered dendritic cells that have been transfected witli genes encoding tumor-associated antigens provides an intriguing combination of gene tlierapy and immunotherapy . ... [Pg.235]

Numerous variables can lead to a negative result from passive immunotherapy. Too little antibody can result in a lack of protective efficiency. Too much antibody can produce a prozone-like effect, whereby more antibody provides less protection than less antibody. The antibodies used in therapy can also be affected by affin-ity/avidity, specificity, isotype, idiotype, preparation, and route of administration. The genetic background and immune competency of the host can also affect treatment as can route of pathogen infection, genetic background, and inoculum size of the pathogen [114]. A dramatic example of the limitations of passive antibody transfer experiments is provided by the observation that transfer of either too little or too much antibody can result in no protection [114]. [Pg.868]

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