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Genetic circuit

Seggerson, K., Tang, L., and Moss, E. G. (2002). Two genetic circuits repress the Caenor-habditis elegans heterochronic gene lin-28 after translation initiation. Dev. Biol. 243, 215-225. [Pg.146]

Noireaux, V., Bar-Ziv, R., and Libchaber, A. (2003). Principles of cell-free genetic circuit assembly. Proc. Natl. Acad. Sci. USA, 100, 12672-7. [Pg.289]

Sprinzak D, Elowitz MB (2005) Reconstruction of genetic circuits. Nature 438 443 448... [Pg.127]

McAdams H. and Arkin A. (1998). Simulation of prokaryotic genetic circuits. Annual Review of Biophysics and Biomolecular Structure. 27, pp 199-224. [Pg.399]

Recent work has constructed genetic circuits in bacteria in which there was a loop of either two [26] or three [27] interacting genes. The transcription factor coded by each of the genes, inhibited the synthesis of the next in the loop. The behavior in this type of network can be modeled by the differential equation... [Pg.155]

EH. (2002) Directed evolution of a genetic circuit. Proc. Natl. Acad. Sci. [Pg.780]

Dasika, M.S. and Maranas, C.D. (2008) OptCircuit an optimization based method for computational design of genetic circuits. BMC Syst. Biol, 2, 24. [Pg.784]

Computing, 2, 47 (2003). Genetic Circuit Building Blocks for Cellular Computation, Communications, and Signal Processing. [Pg.411]

Genetic circuits are collections of basic elements that interact to produce a particular behavior. These elements include DNA regions where RNA poly-... [Pg.121]

Designing operational and efficient genetic circuits will require models and simulation tools that can provide accurate quantitative predictions of circuit behavior. Engineered genetic circuits operate within a highly complex environ-... [Pg.127]

Genetic circuits must integrate specific components or network motifs that make them robust to fluctuations in the kinetics of biochemical reactions. Gene expression tends to be noisy because of the stochastic nature of the constituent biochemical reactions (Elowitz et al., 2002 McAdams and Arkin, 1997). In addition, fluctuations in environmental conditions, such as temperature and nutrient levels, affect cellular metabolism and consequently the operation of genetic circuits. Circuits that achieve reproducible, reliable behavior must do so despite components whose behavior fluctuates considerably. Mitigating the effects of gene expression noise will probably require a solution that incorporates positive and negative feedback loops. [Pg.129]

Weiss, R., S. Basu, A. Kahnbach, S. Hooshangi, D. Karig, R. Mehreja, and 1. Netravali. 2003. Genetic circuit building blocks for cellular computation, communications, and signal processing. Natural Computing, an International Journal 2(1) 47-84. [Pg.130]

Wright S (1931) Evolution in Mendelieui populations. Genetics 16 97-159 Wright S (1988) Surfaces of selective value revisited. Am Nat 131 115-123 Yokobayashi Y, Weiss R, Arnold FH (2002) Directed evolution of a genetic circuit. Proc Natl Acad Sci U S A 99 16587-16591... [Pg.72]

Fig. 5.1 Artificial genetic circuit designed for drug screening... Fig. 5.1 Artificial genetic circuit designed for drug screening...
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See also in sourсe #XX -- [ Pg.253 , Pg.262 ]



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