Genes resistance-associated, identification

Cill, M.J., Brenwald, N.P., and Wise, R. (1999) Identification of an efflux piunp gene, pmrA, associated with fluoroquinolone resistance in Streptococcus pneumoniae. Antimicrobial Agents and Chemotherapy. 43 (1), 187-189. 

In AML cells, ABCG2 is overexpressed however, the association between the expression and clinical resistance to anticancer drugs remains undetermined (81,82). The identification of functional sequence variation in the ABCG2 gene could also be of interest in the field of prognosis of disease. 

Microbiology — Commercial assays are now available for identification of Candida, Psuedomonas, Staphylococcus, and Enterococcus sp. in smears made from blood cultures, and several tests for detection of specific genes associated with drug resistance in Staphylococcus aureus isolates are available in microwell format (3, 4). 

Gahan, L.J., Gould, F., and Heckel, D.G., Identification of a gene associated with Bt resistance in Heliothis virescens, Science, 293, 857, 2001. 

Samimi, G. Manorek, G. Castel, R. Breaux, J.K. Cheng, T.C. Berry, C.C. Los, G. Howell, S.B. cDNA microarray-based identification of genes and pathways associated with oxaliplatin resistance. Cancer Chemother. Pharmacol. 2005, 55, 1-11. 

While progress is being made in this area of plant metabolism, difficulties associated with the isolation of plant microsomal preparations active in the utilization of other herbicide substrates, and with the purification of the active mfo enzymes themselves, are still to be resolved. Consequently, only slow progress has been made on the identification of specific mfo polypeptides suitable as candiates for gene transfer studies. Such studies are aimed at manipulating crop plants for herbicide resistance based on enhanced oxidative detoxification. 

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