Generally Regarded as Safe list

For instance, p-cresol based BHT as an antioxidant will continue to dominate the demand pattern of p-cresol however, two recent developments have put this in doubt. The Food and Drug administration of USA has removed BHT from its GRAS (Generally Regarded As SAFE) list of foodstuff additives on the grounds of suspected carcinogenic properties. This has caused diminished demand of 15% of BHT in USA [8]. 

The dialkyl succinates are good plasticizers for vinyl chloride polymers and copolymers and for cellulose derivatives. SA is also used in the manufacture of alkyd resin to impart flexibility, elasticity, and water resistance. " In addition, it finds numerous applications in the field of adhesives, elastomers, lubricants, pharmaceuticals, pesticides, and epoxy and other resins. Succinic acid is also used as a food acidulant and has been placed on the GRAS (generally regarded as safe) list by the FDA. ... 

Chamomile appears very low in toxicity. It has been listed as Generally Regarded as Safe (GRAS) by the Food and Drug Administration (Tyler 1994). Adverse reactions may include allergic reactions to the pollen in the flowers (Kowalchick and Hylton 1987 Subiza et al. 1990). 

A recent publication by James A. Duke lists the phytochemical constituents of generally-regarded-as-safe (GRAS) herbs (Duke, 2000a). It is also available as a searchable database on disk (WordPerfect 5.1 macros). There is also a volume dealing with 365 herbs having medicinal or folklore medicinal properties (Duke, 2000b). 

Although listed as a GRAS substance [generally regarded as safe) lor many years, questions concerning its safe usage have arisen from time to time and. as of Ihe mid-1980s. MSG still remains somewhat controversial. It is known that overconsumption of MSG can produce art illness, usually... 

Sections 182, 184, 185—Generally Regarded as Safe (GRAS) Lists... 

Table 11.2 summarizes various organic acids that are included in the FDA s list of food additives that are generally regarded as safe (GRAS). 

CNCs are becoming an important class of renewable nanomaterials with many applications in different areas, including biomedicine. A number of reviews on the bioapplications of CNCs can be found in the literature. The U.S. Food and Drug Administration (FDA) has listed CNCs as a Generally Regarded As Safe (GRAS) material. The toxicity assessment of CNCs in the microvascular endothelial cells of human brain was conducted and CNCs were found to be non-toxic to cells and therefore could be used as carriers in the targeted delivery of therapeutics. The non-toxicity of CNCs has been confirmed by interactions with rainbow trout hepatocytes and microvascular endothelial cells. The biocompatibility of CNCs has also been verified in a recent study. " ... 

Molecules from the Generally Regarded As Safe GRAS list http // www.cfsan.fda.gov. Code of Federal Regulations Title 21 - Food and Drugs, http //www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/cfrsearch.cfm, R. C. Rave, P. J. Sheskey and M. E. Quinn, pharmaceutical excipients, in Handbook of Pharmaceutical Excipients, Pharmaceutical Press, New York, 2009. 

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