Generally recognized as safe GRAS substances

essential oils, oleoresins (solvent-free), and natural extractives (including distillates)  

natural extractives (solvent-free) used in conjunction with spices, seasonings and flavorings  

certain other spices, seasonings, essential oils, oleoresins, and natural extracts  

substances migrating from cotton and cotton fabrics used in dry food packaging  

substances migrating to food from paper and paperboard products and 

---

GRAS affirmation process, 12 36. See also Generally Recognized As Safe (GRAS) substances... 

Vanillin is listed in the Code of Federal Regulations by the FDA as a Generally Recognized As Safe (GRAS) substance. The Council of Europe and the FAO/WHO Joint Expert Committee on Food Additives have both given vanillin an unconditional Acceptable Daily Intake (ADI) of 10 mg/kg,... 

Health and Safety. The U.S. FDA has affirmed R%- and S(—)-maHc acid as substances that are generally recognized as safe (GRAS) as flavor enhancers, flavoring agents and adjuvants, and as pH control agents at levels ranging from 6.9% for hard candy to 0.7% for miscellaneous food uses (42). R%- and A(—)-maHc acid may not be used in baby foods. MaHc acid is also cleared to correct natural acid deficiencies in juice or wine (43). 

Health and Safety. The FDA affirmed (R-R, R -tartaric acid as a generally-recognized-as-safe (GRAS) food substance (88). 

Benzaldehyde is a synthetic flavoring substance, sanctioned by the U.S. Food and Dmg Administration (FDA) to be generally recognized as safe (GRAS) for foods (21 CFR 182.60). Both "pure almond extract" and "imitation almond extract" are offered for sale. Each contains 2.0—2.5 wt % benzaldehyde in an aqueous solution containing approximately one-third ethyl alcohol. 

Generally recognized as safe (GRAS) materials/ substances, 11 571, 575 12 34, 35 21 578. See also GRAS affirmation process sodium silicate as, 22 468 Generally recognized as safe (GRAS) procedures, 11 49... 

FDA publishes the first list of "Substances Generally Recognized as Safe" (GRAS), containing nearly 200 substances. 

Determination by the FDA that the substance is generally recognized as safe (GRAS) according to 21 CFR 182,184, and 186... 

The FDA does not require developmental and reproductive toxicity studies for food additives that are classified as generally recognized as safe (GRAS) (3). The acronym unfortunately means fat in French. The FDA maintains an inventory of all GRAS substances (4). Manufacturers may submit GRAS requests for additional substances to the FDA. The inventory includes all GRAS notices and the FDA s reply, whether positive or negative. 

The Food Additives Amendment was added in 1958, requiring manufacturers of new food additives to establish safety. The Delaney proviso prohibited the approval of any food additive shown to induce cancer in humans or animals, and the FDA published the first list of substances, including herbs and spices, as Generally Recognized As Safe (GRAS) in the Federal Register. The list contained nearly 200 substances. This list is now compiled under Title 21 of the Code of Federal Regulations. 

Generally recognized as safe (GRAS) Designation by the USFDA that a chemical or substance (including certain pesticides) added to food is considered safe by experts, and so is exempted from the usual FFDCA food-additive tolerance requirements. 

---