General Concepts of Biocompatibility

Handbook of Biomaterial Properties. Edited by J. Black and G. Hastings. Published in 1998 by Chapman Hall, London. ISBN 0 412 60330 6. 

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Black, J. and G. W. Hastings. 1998. Handbook of Biomaterial Properties. London/New York Chapman and Hall. This is a compilation of data on natural tissues and fluids and how various implantable materials interact with than. The materials covered range from stainless steels, CoCr-based alloys, titanium, and titanium alloys, to thermoplastic polymers and oxide bioceramics. Biocompatibility is discussed with each material and in a chapter on general concepts of biocompatibUity. Available online on Knovel. 

In recent years the concept of introducing H-bonding units into polyesters was used for the synthesis of poly(ester-amide)s and poly(ester-urethane)s, in order to improve the mechanical properties of already known and applied biodegradable polyesters like poly(butylene adipate) . Polycondensation and interfacial polycondensation reactions were applied to obtain materials from various diacids and diamines, amino alcohols or amino acids. In general these materials are biocompatible, biodegradable, and very promising for applications in the biomedical and pharmaceutical field, such as controlled drug delivery devices" . 

Next, general design concepts are discussed to provide cell signaling and scaffold bioactivity via types of polymers with recognized biocompatibility, bioresorbability, mechanical properties structural architecture of the scaffold mass transport and incorporation of biochemical and biophysical cues through siuface target chemistry and topography (Sections 16.4.1 and 16.4.2). 

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