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Gene Spindle

Basu J, Bousbaa H, Logarinho E et al 1999 Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila. J Cell Biol 146 13-28... [Pg.129]

Cheng NN, Kirby CM, Kemphues KJ 1995 Control of cleavage spindle orientation in Caenorhabditis elegans-. the role of the genes par-2 and par-3. Genetics 139 549-559 Edgar LG, Wolf N, Wood WB 1994 Early transcription in Caenorhabditis elegans embryos. Development 120 443—451... [Pg.180]

In the filamentous fungus, Aspergillus nidulans, NIMA (never in mitosis, gene A) kinase phosphorylates H3 at Ser-10 [48]. At mitosis NIMA kinase association with chromatin increases and following metaphase NIMA locates to the mitotic spindle and spindle pole bodies. A human NIMA-related kinase (Nek6) was identified as a putative mitotic HI and H3 kinase [49]. [Pg.209]

The metaphase-anaphase checkpoint controls the formation of the spindle apparatus and the correct alignment of chromosomes, and may initiate metaphase arrest (see Chapter 13). On failure of the control system, the occmrence of abnormal chromosomes is favored. In various cancer cells, chromosomal instabUity is associated with loss of function of the BUBl gene, which is part of the metaphase-anaphase checkpoint (Cahill et al., 1998). [Pg.438]

Parmar, D., Srivastava, S.P., Singh, G.B. Seth, PK. (1995) Testicular toxicity of di(2-ethylhexyl) phthalate in developing rats. Vet. hum. Toxicol., 37, 310-313 Party, E.M. (1985) Tests for the effects on mitosis and the mitotic spindle in Chinese hamster primary liver cells (CHl-L) in cnlture. Prog. Mutat. Res., 5, 479 85 Party, J.M. Eckardt, F. (1985) The detection of mitotic gene conversion, point mutation and mitotic segregation nsing the yeast Saccharomyces cerevisiae strain D7. Prog. Mutat. Res., 5, 261-269... [Pg.141]

BRCAi A Potential Predictive Marker for CiSPLATIN AND DOCETAXEL BRCAi IN THE Transcriptional Regulation OF Spindle Checkpoint Genes Clinical Trials of Customized Chemotherapy References... [Pg.231]

Wang RH, Yu H, Deng CX. A requirement for breast-cancer-associated gene 1 (BRCAl) in the spindle checkpoint. Proc Natl Acad Sci USA 2004 101(49) 17108-17113. [Pg.246]

The application of tensile stresses to osteoblasts appears to cause induction of the BMP-4 gene in preosteoblastic cells and adjacent spindle-shaped fibroblasts suggesting that BMP-4 may play a pivotal role by acting as an autocrine and a paracrine factor for recruiting osteoblasts in tensile stress-induced osteogenesis. Intermittent hydrostatic pressure (IHC) up-regulates osteopontin (OPN) mRNA expression in osteoblast cell cultures. In both... [Pg.248]

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