NIMA kinases

In the filamentous fungus, Aspergillus nidulans, NIMA (never in mitosis, gene A) kinase phosphorylates H3 at Ser-10 [48]. At mitosis NIMA kinase association with chromatin increases and following metaphase NIMA locates to the mitotic spindle and spindle pole bodies. A human NIMA-related kinase (Nek6) was identified as a putative mitotic HI and H3 kinase [49]. 

Letwin, K., Mizzen, L., Motro, B., Ben-David, Y., Berstein, A., and Pawson, T. (1992). A mammalian dual specificity protein kinase, Nekl, is related to NIMA cell cycle regulator and highly expressed in meiotic germ cells. EMBO J. 11 3521-3531. 

Osmani, A. H., McGuire, S. L., and Osmani, S. A. (1991). Parallel activation of the NIMA and p34cdc2 cell cycle-regulated protein kinases is required to initiate mitosis in A. nidulans. EMBO J. 67 283-291. 

Dorin D, Le Roch K, Sallicandro P et al (2001) Pfnek-1, a NIMA-related kinase from the hitman malaria parasite Plasmodium falciparum. Biochemical properties and possible involvement in MAPK regulation. Eur J Biochem 268(9/2600-2608... 

Eto M, Elliott E, Prickett TD et al (2002) lnhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation. J Biol Chem 277 44013 4020... 

Helps NR, Luo X, Barker HM et al (2000) NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centro-somes, is complexed to protein phosphatase 1. Biochem J 349 509-518... 

The NIMA related kinases (Nek) family has four members in the P. falciparum kinome (Pfnek-1, Pfnek-2, Pfnek-3 and Pfnek-4). In other Eukaryotic systems these enzymes appear to play important roles in cell division, including... 

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