Gene expression systemic acquired resistance

Gorlach, J., Volrath, S Knaufbeiter, G. et al. (1996). Benzothiadiazole, a novel class of inducers of systemic acquired resistance, activates gene expression and disease resistance in wheat. Plant Cell 8 629-643. 

A metabolic engineering approach has now provided direct evidence for the role of salicylic acid in systemic acquired resistance. Transgenic tobacco plants were produced expressing the "nah G" gene from Pseudomonas putida, which encodes a salicylate hydroxylase that converts salicylic acid... 

Biologically active compounds induce PR gene expression and systemic acquired resistance in tobacco [109,111]... 

A structurally very similar molecule, tiadinil (11, Fig. 13.3.2), has been shown to have another mode of action as it is an activator of systemic acquired resistance and induces defense gene expression [13]. This illustrates that succinate dehydrogenase inhibitors cannot be recognized based on their structure alone. 

Role of Fatty Acid Desaturases and DHAP Reductase in Systemic Acquired Resistance Systemic acquired resistance (SAR) is an inducible defense mechanism in plants to confer resistance to a broad spectrum of pathogens [59, 60]. SAR is constitutively expressed in the A. thaliana SSI2 mutant. Moreover, the SSI2 gene encodes a stearoyl carrier protein desaturase that catalyzes the conversion of acyl carrier protein-conjugated stearic acid to oleic acid in the plastids [61]. The resulted oleoyl moiety of acyl carrier protein is subsequently transferred to the... 

The in vitro system has some limitations and it can be used only as a model to address acquired drug resistance, because cell lines may not accurately reflect the in vivo situation of patients treated with anticancer drugs. In vivo analysis using patient samples to study anti-cancer drug resistance are described in the published literature. Chang and coworkers (64) showed that the gene-expression patterns from mRNA derived from needle biopsies of breast cancer patients treated with the anticancer drug, docetaxel, could be predictive of response to the therapy. 

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