Gene delivery systems synthetic peptide based

Synthetic peptide-based gene delivery systems consisting of a lysine-rich DNA binding motif and endosomolytic motif have been developed for in vivo gene delivery. One example of such a gene delivery system comprises ... 

To avoid high cytotoxicity and molecular heterogeneity of poly(L-lysine), molecularly homogenous lysine-rich synthetic peptides have been used for gene transfer. It is known that the active sites of enzymes, receptor ligands and antibodies usually involve about 5 to 20 amino acids. Thus, it should be possible to design small synthetic peptides to mimic the active sites of viral proteins and formulate synthetic peptide/DNA complexes that are as efficient as vimses, but do not have their limitations. The major components of a peptide-based delivery systems are ... 

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