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Gene delivery antigenicity

Van Tendeloo, V.F., Ponsaerts, P, Lardon, F., et al. (2001). Highly efficient gene delivery by mRNA electroporation in human hematopoietic cells superiority to lipofection and passive pulsing of mRNA and to electroporation of plasmid cDNA for tumor antigen loading of dendritic cells. Blood, 98, 49-56. [Pg.378]

Tacket, C.O., Roy, M.J., Widera, G., Swain, W.F., Broome, S. and Edelman, R. (1999) Phase 1 safety and immune response studies of a DNA vaccine encoding hepatitis B surface antigen delivered by a gene delivery device. Vaccine, 17, 2826-2829. [Pg.373]

Transdermal vaccination or transcutaneous immunization, is attractive, because it does not require specially trained personnel necessary for needle injections. Topical application of antigens to intact skin has shown promising results for the administration of DNA-based vaccines. Noninvasive gene delivery by pipetting adenovirus- or liposome-complexed plasmid DNA onto the outer layer of skin was able to achieve localized transgene expression within a restricted subset of skin in mice. It also elicited an immune response against the protein encoded by the DNA. ... [Pg.3919]

Kim, T. H., Nah, J. W., Cho, M. H., Park, T. G., Cho, C. S. 2006b. Receptor-mediated gene delivery into antigen presenting cells using mannosylated chitosan/DNA nanoparticles. J. Nanosci. Nanotechnol. [Pg.389]

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See also in sourсe #XX -- [ Pg.253 ]



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