Gene delivery devices

Tacket, C.O., Roy, M.J., Widera, G., Swain, W.F., Broome, S. and Edelman, R. (1999) Phase 1 safety and immune response studies of a DNA vaccine encoding hepatitis B surface antigen delivered by a gene delivery device. Vaccine, 17, 2826-2829. 

To date, LTP has been extensively applied for preparing drug- and gene-delivery devices. Shortly after its development less than a decade ago, Yun has successfully prepared nanoparticles (Figure 12.4) [9,28,29] and microspheres (Figure 12.5) with this polymer and applied them in a wide... 

Another two types of supported dendrons used for generation of dendritic gene delivery devices are the polystyrene-bound polyurea and peptoid dendrons developed by Bradley and coworkers. They demonstrated that these dendrons, once cleaved from the support, complex efficiently plasmid DNA and transfect it successfully into cells. The highest efficiency (comparable or better than that displayed by the commercial transfection agent Superfect) was observed for bis-G3 dendrons capped with lysine. In general, the efficiency increased with the dendron generation (positive effect). 

Fig.1 A PAMAM-capped mesoporous silica nanosphere-based gene delivery device...

Niidome and coworkers studied a G6 dendritic poly(L-lysine) (K6G) as a non-viral gene delivery device [19]. L-lysine has two primary amine moieties that serve to hnk with two other lysines through amide bonds, thus cre-... 

Hatakeyama H, Akita H, Harashima H (2011) A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect a strategy for overcoming the PEG dilemma. Adv Drug Deliv Rev 63 152-160... 

Moriguchi, R., Kogure, K., Akita, H., Futaki, S., Miyagishi, M., Taira, K., and Harashima, H. (2005) A multifunctional envelope-type nano device for novel gene delivery of siRNA plasmids. International Journal of Pharmaceutics 301 277-285. 

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