Matrices, gene-activated

A method was recently developed to deliver plasmid DNA locally to cells involved in wound repair (Bonadio et al., 1999 Fang et al., 1996 Shea et al., 1999). The technique involves the introduction of a porous, biodegradable polymer matrix into the wound site (Bonadio et al., 1998). The scaffold (a gene activated matrix, or GAM), in its simplest form comprises plasmid DNA and the polymer matrix (Bonadio, 2000). Naked 

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Berry M, et al. (2001). Sustained effects of gene-activated matrices after CNS injury. Mol. Cell Neurosci. 17 706-716. 

Cationic Polymers as Gene-Activated Matrices for Biomedical Applications... 

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