Gene-activated matrices as dendrimers

Dendrimers represent a class of versatile well-defined highly branched 3D synthetic polymers, in which growth emanates from a central core molecule such as ammonia, ethylenediamine, propylenediamine or 

Szoka and Haensler investigated the application of PAMAM dendrimers as non-viral vectors for in vitro gene transfer. Their study demonstrated that complexes consisting of G5 PAMAM dendrimers and DNA expression plasmids enhanced transfection efficiency over naked plasmid DNA in many cells, particularly cell lines derived from monkey and human neoplasms. PAMAM cascade polymers mediate efficient transfection of cells in culture. The efficiency of intact dendrimers as synthetic vectors for the delivery of genetic material into cells has also been demonstrated. 

In recent years, Peng et al. have developed a series of structurally flexible triethanolamine (TEA)-core PAMAM dendrimers, which bear primary amines 

Jewell and D. M. Lynn, Curr. Opin. Colloid Interface Set, 2008,13, 

Takemoto, H. Kawata, T. Soeda, K. Imagawa, S. Somekawa, Y. Takeda, 

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