Polymers as Gene-Activated Matrices for Biomedical Applications

Cationic Polymers as Gene-Activated Matrices for Biomedical Applications 

MAMONI DASH, DAVID L. KAPLAN, PETER DUBRUEL AND SANGRAM K. SAMAL  

Polymer Chemistry Biomaterials Research Group, Ghent University, Krijgslaan 281, S4-Bis, B-9000 Ghent, Belgium Department of Biomedical Engineering, 4 Colby Street, Tufts University, Medford, MA 02155, USA  

Laboratory of General Biochemistiy and Physical Pharmacy, Center for Nano- and Biophotonics, Ghent University, Ottergemsesteenweg 460, B-9000, Gent, Belgium Email SangramKeshari.Samal UGent.be 

A cyelodextrin-based supramolecular hydrogel system with eationic co-polymer/plasmid DNA (pDNA) polyplexes was studied as a sustained gene delivery carrier. Biodegradable triblock copolymers of metho3gr-poly(ethylene glycol)-Z)-poly(E-caprolactone)-Z)-poly[2-(dimethylamino)ethyl methacrylate] 

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