Gene-activated matrices as nanoparticles

A non-viral vector PEG-PEI was investigated in the delivery of siRNA to neural stem cells (NSCs). The SEM micrographs showed that PEG-PEI could condense siRNA to form spherical nanoparticles. The gene knockdown effect of PEG-PEI/siRNA nanoparticles was verified at the levels of mRNA and protein, which suggested that PEG-PEI may potentially be used as a siRNA delivery vector for neural regeneration therapy.  

An interesting design and synthesis of cationic star polymers as novel delivery vehicles for siRNA to silence genes in pancreatic and lung cancer cells was developed. (Dimethylamino)ethyl methacrylate (DMAEMA) was 

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