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Gastrointestinal tumors antigens

Amplification of HER-2/neu is found in breast, ovarian, and gastrointestinal tumors. In breast cancer, it appears to be as useful a prognostic indicator of overall survival as tumor size or ER and PR expression, but not as good as the number of lymph nodes involved in metastases. Elevated serum HER-2/neu antigen levels have been shown to correlate witli decreased response to hormone therapy of breast cancer. Of the three oncogenes—HER-2/ e , ras, and c-myc— HER-2/neu has the strongest prognostic value in breast cancer. [Pg.781]

Serum cancer antigen 125 (CA-125) is the most extensively evaluated tumor marker for ovarian cancer. Unfortunately, the CA-125 determination is non-specific, and elevated levels can be associated with a number of other gynecologic and gastrointestinal diseases. CA-125 levels in a woman without ovarian cancer, though, are static or tend to decrease over time, whereas levels associated with malignancy will continue to rise.10 Since CA-125 is a non-specific marker, there is no standard recommendation for routine screening for prevention of ovarian cancer. [Pg.1386]

CEA—Carcinoembryonic antigen Mostly in tumors of gastrointestinal system... [Pg.55]

Guler ML, Daniels JA, Abraham SC, Montgomery EA. Expression of melanoma antigens in epithelioid gastrointestinal stromal tumors a potential diagnostic pitfall. Arch Pathol Lab Med. 2008 132 1302-1306. [Pg.538]

Miettinen M, Virolainen M, Maarit Sarlomo R. Gastrointestinal stromal tumors—value of CD34 antigen in their identification and separation from true leiomyomas and schwannomas. Am J Surg Pathol. 1995 19 207-216. [Pg.538]

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