Gastrointestinal tract adverse reactions/toxicity

No information was located regarding the mechanism by which tetryl enters the blood stream from the lungs, skin, or gastrointestinal tract, the mechanism by which tetryl is transported in the blood stream, or the mechanism of toxicity for tetryl. Earlier studies suggested that the cause of tetryl-induced dermatitis, which is the most common and widely studied adverse effect, may be both physical (direct irritation by sharp tetryl crystals) and chemical (by reacting with components of the skin) (Ruxton 1917). The chemical hypothesis was later advanced by others as well (Bain and Thompson 1954 Brownlie and Cumming 1946). Bain and Thompson (1954) specifically suggested that histamine release may result from a tetryl-induced sensitization reaction or from direct tetryl-induced release from mast cells. 

The most common adverse effects of fusidic acid are minor and are related to the gastrointestinal tract (discomfort, diarrhea). Rare adverse events include granulocytopenia, thrombocytopenia, venous spasm, and skin reactions (4). Fusidic acid has detergent properties and can cause hemolysis when injected intravenously or can induce tissue damage when given intramuscularly. However, its systemic toxicity is relatively low. 

Tetracycline (chlortetracycline) and oxytetracycline These tetracyclines are incompletely absorbed from the gastrointestinal tract. Plasma concentrations fall with half-lives of 6-12 hours. They are predominantly excreted by the kidney, extrarenal elimination amounting at most to 10-20%. They have a lower affinity for fat and membranes, which means that higher dosages to achieve therapeutic effectiveness. However, higher dosages can contribute to an increased risk of systemic toxic effects and, as absorption from oral administration is incomplete, also to an increased risk of gastrointestinal adverse reactions. 

Until relatively recently, chemotherapy has not discriminated effectively between rapidly dividing tumor cells and normal cells, in particular cells in the bone marrow and gastrointestinal tract. This has led to toxic effects for patients including an array of severe nonimmune adverse reactions as weU as hypersensitivities ranging from mild skin manifestations to life-threatening cutaneous and systemic reactions. Effective targeted therapies with high specificity toward tumor cells but broad therapeutic application and absence of toxicity have always been... 

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