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Gastrointestinal stromal tumors GIST

Gastrointestinal stromal tumor (GIST) Mutation c-KIT c-KIT(tyrosi ne-kinase activity) Imatinib, Dasatinib, Sunitinib... [Pg.51]

In this regard, our laboratory demonstrated a method for the quantification of STI571 and its main metabolite, CGP 74588, in human plasma using a semi-automated PPT method and a relatively rapid LC/APCI/MS/MS analysis. The assay exhibited an excellent linearity from 4.00 to 10,000 ng/mL in human plasma. The method was utilized for the analysis of thousands of clinical samples. Furthermore, the method was routinely amenable to analysis of STI571 and CGP 74588 in cerebrospinal fluids (CSF), gastrointestinal stromal tumor (GIST) biopsy specimens, and toxicokinetic studies (data not shown). [Pg.628]

Van Oosterom AT, Judson I, Verweij J, Di Paola E, Van Glabbeke M, et al. 2001. STI 571, an active drug in metastatic gastrointestinal stromal tumors (GIST), an EORTC phase I study. Proc. Am. Soc. Clin. Oncol. 20 1 (Abstr.)... [Pg.220]

Mutational analysis of gastrointestinal stromal tumors (GISTs) procedural approach for diagnostic purposes. Cancer Genomics Proteomics 10 115-523... [Pg.65]

Commercial antibodies to caldesmon are now applied to diagnostic problems in surgical pathology. They appear to be relatively specific for smooth muscle differentiation and, as such, are useful adjuncts to des-min and actin immunostains." " Caldesmon is also expressed in the majority of gastrointestinal stromal tumors (GISTs), glomus tumors, and myopericytomas, and is therefore not entirely specific." >"9... [Pg.92]

MiettinenM, Lasota J. Gastrointestinal stromal tumors (GISTs) definition, occurrence, pathology, differential diagnosis and molecular genetics. Pol Pathol. 2003 54 3-24. [Pg.537]

Herawi M, Montgomery EA, Epstein JL Gastrointestinal stromal tumors (GISTs) on prostate needle biopsy a clinicopathologic study of 8 cases. Am J Surg Pathol. 2006 30 1389. [Pg.653]

Although only one primary uterine gastrointestinal stromal tumor (GIST) has been reported, rectal examples may occasionally be mistaken for fibroids. Spindle cell examples would then suggest leiomyoma or perhaps even leiomyosarcoma, and epithelioid varieties could mimic an epithelioid smooth muscle tumor, carcinoma. [Pg.715]


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See also in sourсe #XX -- [ Pg.447 , Pg.707 ]




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GIST

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Gastrointestinal tumor

Stromal

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