Gastroesophageal reflux disease, asthma

Simpson WG. Gastroesophageal reflux disease and asthma. Diagnosis and management. Arch Intern Med 1995 155 798-803. 

Up to 90% of adult-onset asthma is the result of gastroesophageal reflux disease (GERD). Treating the gastric reflux will treat the asthma. 

Indications for antagonists Allergy, pruritus Gastroesophageal reflux disease, peptic ulcer Sleep and cognition disorders Pruritus, asthma ... 

Proton Pump Inhibitors, Gastroesophageal Reflux Disease, and Asthma... 

There appears to be a higher incidence of asthma in children with gastroesophageal reflux disease (prevalence estimated to be 34-89 %), and this has prompted the suggestion, and the belief seemingly supported by some studies, that PPI treatment of these children may lead to an improvement in asdima symptoms. Three randomized trials showed that PPIs had a beneficial effect on asthma symptoms but one randomized, double-blind, placebo-controlled trial failed to show that omeprazole improved symptoms. At present, there is not enough data from well constructed and controlled clinical trials to reach a confident and conclusive decision on this question. 

Ligand-gated ion channels Allergy, asthma, epilepsy, gastroesophageal reflux, inflammation, ischemia, learning and memory, migraine, neurodegenerative diseases, stroke... 

Sleep disorders associated with other chronic medical conditions, for example, asthma, chronic lung disease, cystic fibrosis, chronic pain, kidney and liver failure, congestive heart failure, gastroesophageal reflux, thyroid disorders, and menopause. 

Gold B (2005) Asthma and gastroesophageal disease in children exploring the relationship. J Peds 146 S13-S20 Gorenstein A, Cohen AJ, Cordova Cet al (2001) Hiatal hernia in pediatric gastroesophageal reflux. J Pediatr Gastroenterol Nutr 33 554-557... 

---