Gastric secretion inhibitors

In addition, Pfister and coworkers investigated 3-hydroxyflavone-6-carboxylic acids as histamine induced gastric secretion inhibitors. After condensing 3-acetyl-4-hydroxybenzoic acid (45) with a variety of aldehydes 46 to deliver the chalcones 47, these purified chalcones were then subjected to the standard AFO conditions to afford flavonols 48 in 51-80% yield. Subsequent alkylation of 48 with methyl iodide or isopropyl iodide followed by saponification of the corresponding esters gave the target compounds. [Pg.501]

The most potent among the compounds tested were the pyridazi-nones (28, R1 = Ph, R2, R3, R4, R5 = H, n = 2-5) [101]. Structure-activity relationships have been investigated in detail with this type of compound. Also, thio-analogues of compounds (28) (3-pyridazinethione derivatives) as well as 2-aminoalky]-6-aryl-3(2//)-pyridazinones were claimed in patents as gastric secretion inhibitors or anti-ulcer agents [100, 102, 103]. [Pg.9]

A 11 COCII NRlR2 t-Pyridyl 11 Gastric secretion inhibitor in rats 920, 1655... [Pg.81]

Esaprazole, l-(A-cyclohexylcarbamoylmethyl)piperazine, gastric secretion inhibitor antiucerogenic [64204-55-3],... [Pg.242]

K30. Kubo, K., Nishi, S., Miyake, T., Yoshizaki, R., and Miyoshi, A., Assay of gastric secretion inhibitor in vivo and in vitro, with special reference to gastric juice of patients with carcinoma of the stomach. Jap. Arch. Internal Med. 9, 494-501 (1962). [Pg.358]

Several sulfamoylamidine derivatives have shown7 activity as histamine H2 receptor antagonists and are valuable as gastric secretion inhibitors (see Chapter 11, p. 232), e.g. 3-(4-thiazolemethylthio) propionamidines (149), prepared by Lewis acid catalysed reaction of the propionitrile (150) with sulfamide (136) (Scheme 61). [Pg.172]

BL 6341A is a thiazolylguanidine derivative, a HISTAMINE H2-RECEPTOR ANTAGONIST. It is a GASTRIC SECRETION INHIBITOR, and potentially an ANTIulcerogenic. [Pg.52]

Dimotapp hrompheniramine. dimoxaprost [inn] (Hoe 260) is a prostaglandin and PROSTANOID RECEPTOR AGONIST, with potential GASTRIC SECRETION INHIBITOR and ANTIULCEROGENIC activity. [Pg.101]

It can be used orally to treat infection by the herpes viruses, famotidine [ban. inn, usan[ (YM 11170 L 643341 MK 208 Pepcid ) is a thiosulfamoylpropionamidine, a histamine Hj-RECEPTOR ANTAGONIST. It is a GASTRIC SECRETION INHIBITOR and ANTIULCEROGENIC. It is also suggested to be beneficial in the treatment of schizophrenia, and as an antiviral. famprofazone [ban. inn] is one of the pyrazolone series of cyclooxygenase inhibitors with nsaid analgesic. [Pg.118]

FCE 23067 is a guanidothiazolopyridine, a HISTAMINE Hj-RECEPTOR ANTAGONIST. It is a potential gastric secretion INHIBITOR and ANTIULCEROGENIC. [Pg.118]

GASTRIC SECRETION INHIBITORS act at some stage in the control process to inhibit the enzymic or gastric acid... [Pg.130]

GEA 6414 tolfenamic acid, gefarnate (ban, inn] (geranyl farnesylacetate) is a tetradecatrienoate, which has been used as a gastric SECRETION INHIBITOR and ANTIIJLCEROGENIC for the treatment of peptic ulcers and other gastrointestinal disorders. GelTears carbomer. [Pg.131]

AH 23844) is a piperidinyltriazole, a HISTAMINE H2-RECEFTOR ANTAGONIST, with GASTRIC SECRETION INHIBITOR and ANTIULCEROGENIC properties. [Pg.161]

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