Gastric acid secretion inhibitors ulcer disease

Gl disease/dysfunction Tacrine is an inhibitor of cholinesterase and may be expected to increase gastric acid secretion caused by increased cholinergic activity. Therefore, closely monitor patients at increased risk for developing ulcers for symptoms of active or occult Gl bleeding. 

Clinical Studies with Ha-Receptor Antagonists. HA Hz-receptor antagonists are potent and selective inhibitors of gastric acid secretion, with numerous clinical studies to support their effectiveness in ulcer disease. Table 3.4 outlines the clinical effectiveness and pharmacokinetic profile of Hz-receptor antagonists currently available in the UK. 

H2-receptor antagonists are quite effective in some peptic acid disorders (duodenal ulcers, gastric ulcers), whereas their effectiveness in others is less apparent (Zollinger-Ellison syndrome, gastrooesophageal reflux disease) [22]. For such conditions, prolonged and potent reduction of acid secretion caused by H /K -ATPase inhibitors is necessary and results in superiority of omeprazole over H2-receptor antagonists [25, 26]. 

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