Gastric-releasing peptide receptors

Bombesin peptide Bombesin was conjugated to JV-acetyl histidine-modified GC for targeting gastric-releasing peptide receptors overexpressed in prostate cancer cells. Iron oxide was loaded to be tested as a probe for MRI [34]... 

Calcitonin Receptor-Like Calcitonin Receptor Corticotrophin Releasing Fact s Cortlcotrophln Releasing Fa> Corticotrophin Releasing Factor Gastric Inhibitory Peptide Receptor Glucagon>llke Receptor... 

As the volume of the chyme in the duodenum increases, it causes distension of the duodenal wall and stimulation of mechanoreceptors. This receptor stimulation elicits reflex inhibition of gastric motility mediated through the intrinsic and vagus nerves. Distension also causes release of gastric inhibitory peptide from the duodenum, which contributes to inhibition of gastric contractions. 

Varga G, Liehr RM, Scarpignato C, Coy DE (1995) Distinct receptors mediate gastrin-releasing peptide and neuromedin B-induced delay of gastric emptying of liquids in rats. Eur J Pharmacol 286 109-112... 

Hersey. S.J. et al. (1995) Gastric acid secretion. Physiol. Rev.. 75.155-190. antalarmin is a synthetic non-peptide CORTICOTROPHIN-RELEASING factor RECEPTOR ANTAGONIST which is more active at the CRF subtype. It is used as a pharmacological tool, antazoline (ban.inn) (antazoline phosphate [usan] antazollne sulphate imidazolamine phenazoline ... 

Rossowski WJ, Gu ZF, Akarca US, Jensen RT, Coy DH (1994) Characterization of somatostatin receptor subtypes controlling rat gastric acid and pancreatic amylase release. Peptides 15 1421-1424... 

There are several steps in the absorption of vitamin B. In the stomach and lumen of the small intestine it is hydrolysed from its (peptide) links with the proteins of which it is a component. It then attaches to gastric intrinsic factor, which is a glycoprotein of molecular mass about 50 000 kDa, to form a complex. This protects the vitamin from being damaged by acid in the stomach. The complex is carried into the ileum, where it binds to a receptor on the surface of the absorptive cells and is released from the intrinsic factor within the absorptive cell, hi the portal venous blood, it is transported to the liver bound to the vitamin B 12-binding protein, which also protects the vitamin. 

Secretin inhibits postprandial gastrin release (thus decreasing gastric acid secretion) and increases pancreatic exocrine secretion (e.g. of bicarbonate). The secretin receptor (like the GLP-1 receptor and vasoactive intestinal peptide (VIP) receptor) acts via Gas and cAMP elevation. A plant agonist for the secretin receptor has been isolated from the Thai anti-ulcer plant Croton sublyratus (plau-loi) (Table 5.8). 

Pentagastrin is a short peptide that stimulates the production of gastric acid from the stomach by a direct action on gastrin receptors and of calcitonin from thyroid C cells (1). It also acts on cholecystokinin receptors centrally and stimulates the release of adrenocorticotropin (ACTH) and hence the production of glucocorticoids (2). 

Isolation and discovery of ghrelin support another control system for GH release in addition to GH-RH and SRIF. Ghrelin is a small 28 amino acid (AA) peptide released from neuroendocrine cells in the gastric mucosa that binds to the GH secretagogue receptor to induce the secretion of both GH-RH and GH itself. Ghrelin also induces food intake and the development of obesity. 

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