Glucagon Receptors

Other uptake-linked receptors found on the SECs are the Fc receptor for the uptake of immunoglobulins [19], the CD14 receptor for the binding of lipopolysaccharide (EPS) bound to EPS binding protein [20], the platelet derived growth factor AA receptor [21] and the glucagon receptor [22]. 

R. Iyengar (1986). Structural characterization of the glucagon receptor. In N. Kraus-Friedman (Ed.). Hormonal Control of Gluconeogenesis, vol. 2. Boca Raton CRC Press, pp. 21-34. 

A. Ling (2002). Small-molecule glucagon receptor antagonists. Drugs Put. 27 987-993. 

Members of the Gs subfamily are activated by hormone receptors, by odor receptors and by taste receptors. Gg-proteins mediate, e.g., signal transmission by adrenaline receptors of type P and by glucagon receptors. During perception of taste, the taste receptors are activated, which then pass the signal on via the olfactory G-protein Gou. Perception of sweet taste is also mediated via a Gs-protein. Transmission of the... 

The function of the enteroglucagons has not been clarified, although smaller peptides can bind hepatic glucagon receptors where they exert partial activity. A derivative of the 37-amino-acid form of GLP-1 that lacks the first six amino acids (GLP-1 [7-37]) is a potent stimulant of insulin release. It represents the predominant form of GLP in the human intestine and has been termed "insulinotropin." It has been considered as a potential therapeutic agent in type 2 diabetes. 

T. L. Jetton, and K.T. Demarest. 2004. Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice. Diabetes 53 410-417. 

Metabolic Effects of Mutant Enzymes Predict and explain the effect on glycogen metabolism of each of the following defects caused by mutation (a) loss of the cAMP-binding site on the regulatory subunit of protein kinase A (PKA) (b) loss of the protein phosphatase inhibitor (inhibitor 1 in Fig. 15-40) (c) overexpression of phosphorylase b kinase in liver (d) defective glucagon receptors in liver. 

The glucagon receptor is a member of the G-protein-coupled family of receptors. 

C. G-protein as link between glucagon-receptor and adenylate cyclase... 

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