Gangliosides brain distribution

KIO. Koenig, H., Histological distribution of brain gangliosides lysosomes as glyco-lipidoprotein granules. Naiure (London) 195, 782-784 (1962). 

Sheikh KA, Deerinck TJ, Ellisman MH, Griffin JW (1999) The distribution of ganglioside-like moieties in peripheral nerves. Brain 122 449-460. 

Koenig, H., Gaines, D., McDonald, T., Gray, R. and Scott, J. (1964) Studies of brain lysosomes. 1. Subcellular distribution of five acid hydrolases, succinate dehydrogenase and gangliosides in rat brain. J. Neurochem., 11, 729-743. 

Sphingolipids (sulfatide, ganglioside GM2, and asialo-GM2 (GA2)) were distinctly visible in hexb / mouse brain samples by using OCN for matrix application. These ion images clearly demonstrate that the OCN system is useful for sample preparation for imaging MALDTMS of lipids. The spatial distribution of sulfide subspecies ST dl8 l/C22 0 m/z 862.6), ST(OH) dl8 l/h22 0 m/z... 

Studies with IMS of lipids can address many specific scientific questions related to the distributions of particular types of lipids. For instance, determination of the distribution of GPL speeies containing polyunsaturated fatty acids in a particular type of cells in a mouse brain section [57] of gangliosides in different regions of the brain [73] of ST in different layers of rat hippocampus [74] and of PC and GalCer species in rat brain sections [75] has all been well addressed. 

Vajn K, Viljetic B, Degmecic IV, Schnaar RL, Heffer M. Differential distribution of major brain gangliosides in the adult mouse central nervous system. PloS One. 2013 8(9) e75720. 

Kotani, M. Tai, T. An immunohistochemical technique with a series of monoclonal antibodies to gangliosides their differential distribution in the rat cerebellum. Brain Res. Brain Res. Pro-toc. 1997, 152-156. 

There is a considerable literature on the distribution of sialic-acid-containing complex glycolipids (gangliosides) in brain and its components (Burton et aL, 1965 Wolfe, 1961 Lapetina et aL, 1967 Wiegandt, 1967 Wherrett and Mcllwain, 1962 Eichberg et aL, 1964 others). The gangliosides, whose function is essentially unknown, are concentrated in the grey matter. 

Roukema, P. A., and Heijlman, J., 1970, The regional distribution of sialoglycoproteins, gangliosides and sialidase in bovine brain, J. Neurochem. 17 773-780. 

---