Ganglioside Structure

A. A. Wolf, M. G. Jobling, S. Wimer-Mackin, M. Ferguson-Maltzman, J. L. Madara, R. K. Holmes, and W. I. Lencer. Ganglioside structure dictates signal transduction by cholera toxin and association with caveolae-like membrane domains in polarized epithelia. J Cell Biol. 141 917-927 (1998). 

Wolf, A.A, Jobling, M.G., Wimer-Mackin, S., Madara, J.L., Holmes, R.K., and Lencer, W.L, 1998. Ganglioside structure dictates signal transduction by cholera toxin in polarized epithelia and association with caveolae-like membrane domains. J. Cell Biol., 141, pp. 917-927. 

Table 2.2 Ganglioside structure and occurrence (from Gurr and James (1980) with permission)... 

GANGLIOSIDE STRUCTURE, FUNCTION AND BIOMEDICAL POTENTIAL Edited by Robert W. Ledeen, Robert K. Yu, Maurice M. Rapport, and Kunihiko Suzuki... 

Specifically, we are investigating the effect of lipid doping on the microstructural morphology ofZ.-Glu-Bis-3 assemblies widi the addition of Gmi ganglioside (structure shown below), a known receptor of cholera toxin, and/or cholesterol. Gangliosides are a mily of glycosphingoUpids localized to the outer leaflet of the plasma menibrane of vertebrate cells. When inserted into... 

Figure 5.12 Ganglioside Structures and Enzymes Cleavage sites. After Pearce and Buchanan (1980)...

At least 40 different ganglioside structures have been established during the last 20 years (HAkkinen and Kulonen 1963, Kuhn and Wiegandt 1964, Hakomori 1966, Tettamanti et al. 1964, Svennerholm 1963, Penick and McCluer 1965, Ando and Yu 1979) and quite recently even fucose-containing... 

Fishman, P. H., Moss, J., and Vaughan, M., 1976, Uptake and metabolism of gangliosides in transformed mouse fibroblasts. Relationship of ganglioside structure to choleragen response, /. Biol. Chem. 251 4490. 

Ando, S., Yu, R. K., Scarsdale, J. N., Kusunoki, S., and Prestegard, J. H., 1989, High resolution proton NMR studies of gangliosides. Structure of two types of GD3 lactones and their reactivity with monoclonal antibody R24, J. Biol. Chem. 264 3478-3483. 

Ledeen, R., 1970, New developments in the study of ganglioside structures, Chem. Phys. Lipids 5 205. 

Several other variants of basic ganglioside structures have been reported. Glucosamine-containing gangliosides have been detected since the very early studies (reviewed by Martensson, 1969). The structures of four of these gangliosides have been elucidated recently (Li et al., 1973 Wiegandt, 1973, 1974). 

Basic ganglioside structure without A/-acetyl neuraminic acid (sialic acid) residues. Intermediate in ganglioside biosynthesis (rat, frog, brain)... 

---