Specificity gangliosides, structure

Specifically, we are investigating the effect of lipid doping on the microstructural morphology ofZ.-Glu-Bis-3 assemblies widi the addition of Gmi ganglioside (structure shown below), a known receptor of cholera toxin, and/or cholesterol. Gangliosides are a mily of glycosphingoUpids localized to the outer leaflet of the plasma menibrane of vertebrate cells. When inserted into... 

Hirabayashi, Y. Nakao, T. Irie, F. Whittaker, V. P. Kon, K. Ando, S. Structural characterization of a novel cholinergic neuron-specific ganglioside in bovine brain. J. Biol Chem. 1992, 267 12973-12978. 

As in the case of the gangliosides in vertebrates, the sialoglycolipids in sea urchins are cell-surface antigens. A study of antigenic specificity for two disialoglycolipids (from the eggs of S. intermedius) whose structures differ in only one respect, that a sulfate group is present on the sialic acid... 

More recently, studies on Campylobacter jejuni have demonstrated how specific bacterial carbohydrate antigens can mimic the fine structure of human cell surface glycolipid structures and elicit autoimmune reactivity. Yuki et al.61 first identified that the lipooligosaccharide (LOS) of C. jejuni mimicked human G(M)1 ganglioside and subsequently extended these studies to demonstrate that specific single amino acid variants of the C. jejuni Cst-II sialyltransferase protein are responsible for the synthesis of LOS variants that in turn, mimic different... 

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