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GABA reuptake inhibitor

Tiagabine is an anti-convulsive medication also used in the treatment for panic disorder as are a few other anticonvulsants. It does appear to operate as a selective GABA reuptake inhibitor. Tiagabine s most common side effects include confusion, difficulty speaking clearly/stuttering and mild sedation. [Pg.359]

Release of aspartate and glutamate Glutamate release antagonist GABA reuptake inhibitor... [Pg.760]

Anticonvulsant selective GABA reuptake inhibitor (SGRI)... [Pg.457]

S-hydroxy (106) <94T8699> analogues of the novel GABA reuptake inhibitor, tiagabine, are reported. The key intermediate in each report is the cyclopropyl alcohol 107. 3-Substituted thieno[2,3-b][l,4]thiazine-6-sulfonamides 108 are a novel class of topically active carbonic anhydrase inhibitors (CAIs). None of these compounds wae as active as the thienothiopyran-2-sulfonamide clinical... [Pg.97]

Tiagabine is a specific inhibitor of GABA reuptake into glial cells and other neurons. [Pg.609]

As we move forward with our discussion, we ll devote a section of this chapter to each of the key neurotransmitter systems that psychotropic medications interact with. We will discuss the following systems norepinephrine, dopamine, serotonin, GABA, acetylcholine, and histamine. Within each of the sections is a description of the effects that can be anticipated when a medication enhances the activity of that transmitter (reuptake inhibitors or agonists), and the effects to expect when a medication interferes (receptor antagonists) with the activity of that same transmitter. We will then describe strategies that can be implemented to help minimize and/or manage these side effects. [Pg.355]

They are different from vigabatrin (4) in that they are not inhibitors of GABA transaminase, and, in contrast to tiagabine (5), these molecules do not directly inhibit GABA reuptake (Bryans and Wustrow, 1999 Taylor, 1994). [Pg.227]

Mitsushima D, Hei DL, Terasawa E GABA is an inhibitory neurotransmitter restricting the release of luteinizing hormone-releasing hormone before the onset of puberty. Proc Natl Acad Sci USA 91 395-399, 1994 Miura N, Nakata N, Tanaka Y, et al Improving effects of FG-7080 a serotonin reuptake inhibitor on scopolamine-induced performance deficits of memory tasks in rats. Jpn J Pharmacol 62 203-206, 1993 Mizuta T, Segawa T Chronic effects of imipramine and lithium on 5-HT receptor subtypes in rat frontal cortex, hippocampus and choroid plexus quantitative receptor autoradiographic analysis. Jpn J Pharmacol 50 315-326, 1989... [Pg.699]

Bhagwagar Z, Wylezinska M, Taylor M, Jezzard P, Matthews PM, Cowen PJ. Increased brain GABA concentrations following acute administration of a selective serotonin reuptake inhibitor. Am J Psychiatry 2004 161(2) 368-370. [Pg.563]

CGRP calcitonin gene-related peptide GABA y-aminobutyric acid 5-HT serotonin, 5-hydroxytryptamine IHS International Headache Society MAOIs monoamine oxidase inhibitors NSAIDs nonsteroidal anti-inflammatory drugs SSRI selective serotonin reuptake inhibitor TCA tricyclic antidepressant... [Pg.1120]

GABA, Y-arninobutyric acid SNRI, serotonin and norepinephrine reuptake inhibitor SSRi, seiective serotonin uptake inhibitor. [Pg.2099]

GABA Rat Hippocampus Electrophysiology (patch clamp) Inhibitor of endocannabinoid reuptake Wilson and Nicoll 2001... [Pg.351]

Examples of drug action on transporter systems include the inhibitors of reuptake of several neurotransmitters, including dopamine, GABA, norepinephrine, and serotonin. [Pg.25]


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See also in sourсe #XX -- [ Pg.347 ]




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