GABA receptors pharmacology

W. Hevers, H. Luddens (1998). The diversity of GABA receptors pharmacological and electrophysiological properties of GABA channel subtypes. Mol. Neurobiol. 18 35. 

There is considerable evidence that GABA is an important neurotransmitter in the CNS of insects, although the details of insect GABA receptor pharmacology are only just beginning to emerge (4-9) ... 

Enna S. J (1981) GABA receptor pharmacology, functional considerations. Biochem Pharmacol. 30, 907-913 Felker P. (1978) Gas-hqmd chromatography of the heptafluorobutyric-O-isobutyl esters of ammo acids. J Chromatogr 153, 259-262 Fonnum F (1981) The Turnover of Transmitter Ammo Acids, With Special Reference to GABA, in Central Neurotransmitter Turnover (Pycock C J. and Tabener P V, eds.) University Press, Baltimore, pp 105-124... 

Pharmacological modulation of GABA -receptor and glycine-receptor channels... 

Egebjerg, Schousboe, and Krogsgaard-Larsen, Eds., Glutamate and GABA Receptors and Transporters Structure, Function and Pharmacology, Taylor Francis, London, 2001. 

GABA receptors have been identified electrophysiologically and pharmacologically in all regions of the brain 293... 

Careful analyses of the pharmacologic properties of 3H-hailucinogen binding sites indicated that they may correspond to 5-HT receptors (in the case of 3H-LSD), sigma opiate receptors (in the case of 3H-PCP), or even GABA receptors (in the case of 3H-muscimol). Such data recall that hallucinogens should interfere markedly with the metabolism of neurotransmitters in the CNS. These hallucinogen-induced alterations of neurotransmitter metabolism and functions are summarized below. 

Agnati, L.F., Ferre, S., Lluis, C., Franco, R. and Fuxe, K. (2003) Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons. Pharmacological Reviews, 55, 509-550. 

Pharmacology Eszopiclone is a nonbenzodiazepine hypnotic. The precise mechanism of action of eszopiclone as a hypnotic is unknown, but its effect is believed to result from its interaction with gamma-aminobutyric acid (GABA)-receptor complexes at binding domains located close to or allosterically coupled to benzodiazepine receptors. 

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