GABA hypotensive effect

Trimipramine is a sedating tricyclic antidepressant that has been used as a hypnotic (1) it shares this activity with other drugs of its class, notably amitriptyline, dosulepin, doxepin, and trazodone, and with the tetracyclics mianserin and mirtazapine. Trimipramine may be preferred for this purpose, since it has less effect on sleep architecture, including REM sleep (2), and has only a modest propensity to produce rebound insomnia in a subset of patients (3). Sedative antidepressants may be particularly appropriate for individuals at risk of benzodiazepine abuse and patients with chronic pain (4). The usual pattern of tricyclic adverse effects, especially antimuscarinic and hypotensive effects and weight gain, can be expected. Some authors, enthusiastic about GABA enhancers, contend that antidepressants are not useful hypnotic alternatives (5). 

It has been reported that GABA was absorbed in the gastrointestinal tract as a specialized transport mechanism which obeys Michaelis-Menten and first-order kinetics [52]. Since the blood-brain barrier is impermeable to GABA [53], the hypotensive effect of peripherally administered GABA is due to the actions of the peripheral nervous system and those of several... 

GABA-rich Chlorella contains GABA, which shows a hypotensive effect associated with the blockade of sympathetic ganglia and hypotensive components such as nucleic acids and proteins in Chlorella cells. Therefore, GABA-rich Chlorella is expected to show a synergistic effect on SHRSP or hypertensive subjects. 

Kimura, M., Hayakawa, K., and Sansawa, H. (2002) Involvement of gamma-aminobutyric add (GABA) B receptors in the hypotensive effect of systemically administered GABA in spontaneously hypertensive rats. Jpn J Pharmacol 89, 388-394. 

Alcohol Theories include combination of effects at receptor and Pi adernergic agonism leading to GABA receptor sensitization to ethanol Sedation and hypotension with coadministration Caution patients to avoid coadministration Lin et al., 1994... 

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