Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Future Biomarker Directions

As an example, Hsieh et al. identified toxicodynamic biomarkers in monkey semm that demonstrated a quantitative relationship with drug exposure (Cr iax, AUC) and related pathological events [148], The biomarkers were used for a more precise calculation of the no observed adverse effect level (NOAEL). The safety of three different dosing schedules was predicted using pharmacokinetic pharmacodynamic (PKPD) modeling and biomarker analysis. [Pg.375]

1 Schuster, D., Laggner, C. and Langer, T. (2005) Why drugs fail-a study on side effects in new chemical entities. Current Pharmaceutical Design, 11 (27), 3545-3559. [Pg.376]

3 Kaplowitz, N. (2005) Idiosyncratic drug hepatotoxicity. Nature Reviews. Drug Discovery, 4 (6), 489 99. [Pg.376]

4 Navarro, V.J. and Senior, J.R. (2006) Drug-related hepatotoxicity. The New England Journal of Medicine, 354 (7), 731-739. [Pg.376]


On the basis of our current knowledge, it is conceivable that K+ channels are viable diagnostic biomarkers and therapeutic targets for human cancers. Nonetheless, it should be emphasized that there is still a long way to go towards obtaining solid proof for this hypothesis. There are many unanswered questions and unsolved problems, and answering these questions will shape the future directions of the research field. Not until the key issues will have been resolved, will the clinical implications of K+ channels in cancer therapy be a reality. [Pg.80]

Future Directions in the Discovery of Toxicity Biomarkers through Computational Approaches 737... [Pg.725]

Jain KK. Cancer Biomarkers Current issues and future directions. Curr Opin Mol Ther 2007 9 563-571. [Pg.266]

TABLE 61.2 CONCLUDING REMARKS AND FUTURE DIRECTIONS Biomarkers for Sulfur Mustard Exposure 921... [Pg.921]


See other pages where Future Biomarker Directions is mentioned: [Pg.374]    [Pg.374]    [Pg.22]    [Pg.16]    [Pg.116]    [Pg.204]    [Pg.160]    [Pg.403]    [Pg.1]    [Pg.252]    [Pg.645]    [Pg.284]    [Pg.729]    [Pg.729]    [Pg.94]    [Pg.844]    [Pg.395]    [Pg.408]    [Pg.11]    [Pg.199]    [Pg.623]    [Pg.240]    [Pg.396]    [Pg.29]    [Pg.131]    [Pg.407]    [Pg.411]    [Pg.1357]    [Pg.166]    [Pg.242]    [Pg.721]    [Pg.313]   


SEARCH



Future Directives

Future directions

© 2024 chempedia.info