Fujita studies

Figure 5.3 illustrates the key features of the Fujita study. In relation to the reference phenol in frame (a), frames (b), and (c) illustrate the effect of H-bonding, and frames (d) and (e) illustrate steric hindrance. Given that the H-bond donor strength of (b) is greater than that of (c), since pKa (b) membrane partitioning, 8, increases in (b) and decreases in (c), relative to (a). Similarly, steric hindrance in (d) produces negative 8, compared to (e). 

Nagao, Y., and E. Fujita Studies for Exploitation of the Biologically Active Components in Enmei-so (Rabdosia japonica Kara and R. trichocarpa Kudo) and Related Plants. Proc. Symp. Wakan-Yaku 13, 79 (1980). 

Y. Abe, H. Oouchi, and Y. Fujita, Studies on pyrethroidal compounds part VII. Factors influencing the vaporization of allethrin from burning mosquito coils, Botyu-Kagaku, 41, 29, 1976. 

S. Hata, H. Fujita, C. G. Shlesier, S. Matsumura, N. Kuwano, K. Oki. Monte Carlo study of ordering processes in fcc-based Ni-Mo alloys. Mater Trans JIM 39 m, 1998. 

FUJITA H, YAMAGAMi T (2001) Fermented soybean-derived Touchi-extract with anti-diabetic effect via alpha-glucosidase inhibitory action in a long-term administration study with KKAy mice. Life Sci. 70 219-27. 

Fujita, T Nishioka, T., Nakajima, M. Hydrogen-bonding parameter and its significance in quantitative structure-activity studies. /. Med. Chem. 1977, 20, 1071-1081. 

Okabe, N., Kuriowa, A., Fujita, K., Shibuya, T., Yao, T. and Okumura, M. (1986). Immunolt cal studies on Crohn s disease. (vi) Increased chemiluminescent response of peripheral blood monocytes. J. Clin. Lab. Immunol. 21, 11-15. 

T. Fujita and T. Ban, Structure-activity study of phenethylamines as substrates of biosynthetic enzymes of sympathetic transmitters. J. Med. Chem., 14 (1971) 148-152. 

T. Fujita, in Comprehensive Medicinal Chemistry the Rational Design, Mechanistic Study and Therapeutic Application of Chemical Compounds, Pergamon Press, Oxford, 1990, pp. 497-560. 

The first case is the one dealt with by Fujita and Kwan (15), Barry (16), and Terenin and Solonitzin (17) who studied a ZnO-02 system, and also by Kennedy et al. (18,19) who worked with a Ti02-02 system On oxidation of the specimen photodesorption was replaced by photoadsorption. Here also belong the papers by Romero-Rossi and Stone (11,12) (ZnO-02) and by Kwan (18) (Ti02-02) who observed, at high temperatures (above 400°C), the replacement of photodesorption by photoadsorption with increasing oxygen pressure (i.e., as the degree of oxidation of the specimen increased). 

Kojima, K. and M. Fujita. 1973. Summary of recent studies in Japan on methyl mercury poisoning. Toxicology 1 43-62. 

Doherty, J.D., K. Nishimura, N. Kurihara, and T. Fujita. 1986. Quantitative structure-activity studies of substituted benzyl chrysanthemates. 9. Calcium uptake inhibition in crayfish nerve cord and lobster axon homogenates in vitro by synthetic pyrethroids. Pestic. Biochem. Physiol. 25 295-305. 

Chapter 5 by M. Fujita and T. Okuyama examines the ringopening reactions of alkylidenecyclopropanone acetals for solvolytic generation and trapping of alkylideneallyl cations (resonance hybrids of 1-vinyl-substituted vinyl cations). In Chapter 6 by V. P. Reddy et al. stable ion and computational studies of cyclobutylmethyl cations are discussed. In Chapter 7, G. I. Borodkin and V. G. Shubin discuss and... 

Fujita Y, Zenitani B, Nakao Y, Matsubara T (1972) Bacteriological studies on diseases of cultured laver. II. Bacteria associated with diseased laver. Bull Jap Soc Sci Fish 36 565-569 Gachon CMM, Kupper H, Kupper FC, Setlik I (2006) Single-cell chlorophyll fluorescence kinetic microscopy of Pylaiella littoralis (Phaeophyceae) infected by ChytricUum pofysiphoniae (Chytridiomycota). Eur J Phycol 41 395—403... 

Fujita et al. [18] studied formation of halogenated (chlorinated and brominated) NPEOs and NPECs during wastewater treatment. Halogenated derivatives were found to be produced during the disinfection processes by chlorination accounting for up to 10% of total nonylphenolic compounds. They were found in 25 of 40 WWTPs with concentrations up to 6.5 xgL 1 in secondary effluent and 52.4 jig L-1 in final effluent. Of all halogenated compounds, BrNPECs (nEo = 1-2) were found to be the most abundant. 

K. Ohno, H. Yoshida, H. Watanabe, T. Fujita, and H. Matsuura, Conformational study of 1 butanol by the combined use of vibrational spectroscopy and ab initio molecular orbital calculations. J. Phys. Chem. 98, 6924 6930 (1994). 

The pioneering studies of Bender s group were followed by many attempts to increase the efficiency of esterolysis by cyclodextrins and several approaches have been tried, most notably in Breslow s laboratory. One may optimize the structure of the substrate (Trainor and Breslow, 1981 Breslow et al., 1983), modify the cyclodextrin (Emert and Breslow, 1975 Breslow et al., 1980 Fujita et al., 1980), or alter the solvent (Siegel and Breslow, 1975). The last of these is the easiest to achieve but detailed studies are made tedious by the necessity to redetermine all of the relevant equilibrium and rate constants, and the acidity dependence of the catalysed and uncatalysed processes, in the new medium. 

I sincerely thank my coworkers whose names appear in the references. Our studies have been supported by operating grants and scholarships from the Natural Sciences and Engineering Research Council of Canada. I am also grateful to Professor Toshio Fujita (Kyoto University) for providing the data necessary for the calculation of Krs for the esters in Tables A5.2 to A5.4. 

Shen Q, Lin Y, Handa T, Doi M, Sugie M, Wakayama K, Okada N, Fujita T, Yamamoto A (2006) Modulation of intestinal P-glycoprotein function by polyethylene glycols and their derivatives by in vitro transport and in situ absorption studies. Int J Pharm 313 49-56. 

Shinoda K, Yagi H, Fujita H, Osawa Y, Shiotani Y. 1989. Screening ofaromatase-containing neurons in ratforebrain an immunohistochemical study with antibody against human placental antigen X-P2 (hPAX-P2). J Comp Neurol 290 502-515. 

Kurihara, N., Uchida, M., Fujita, T., and Nakajima, M. Studies on BHC isomers and related compounds. V. Some physicochemical properties of BHC isomers (1), Pestic. Biochem. Physiol, 2(4) 383-390,1973. 

Terada, M., Iwanaga, T., Takahasi-Iwanaga, H., Adachi, I., Arakawa, M., and Fujita, T. (1992) Calcitonin gene-related peptide (CGRP)-immunoreactive nerves in the tracheal epithelium of rats an immunohistochemical study by means of whole-mount preparations. Arc/t. Histol. Cytol. 55, 219-233. 

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