Fujita, Toshio

Fujita, Toshio, Iwasa, Junkichi, Hansch, Gorwin, J. Amer. Chem. Soc. 

I sincerely thank my coworkers whose names appear in the references. Our studies have been supported by operating grants and scholarships from the Natural Sciences and Engineering Research Council of Canada. I am also grateful to Professor Toshio Fujita (Kyoto University) for providing the data necessary for the calculation of Krs for the esters in Tables A5.2 to A5.4. 

Hansch and Toshio Fujita, a postdoctoral researcher in Hansch s group, designed a parameter, ttr, to estimate the lipophilicity of an R-group.3 Hansch s parameter relies on partition coefficients to measure lipophilicity. Partition coefficients, P, are equilibrium constants describing the degree to which a molecule distributes into a biphasic mixture of two immiscible solvents. Hansch used 1-octanol and water as the model solvents because these were known to simulate the lipid membrane-cytosol interface. The partition coefficient of a molecule is defined as the ratio of a molecule s concentration in an octanol layer to its concentration in an aqueous layer (Equation 12.12). 

Toshio Fujita, QSAR and Drug Design New Developments and Applications, in Pharmacochemistry Library, Vol. 23, Elsevier, Amsterdam, The Netherlands, 1995. 

Corwin Hansch and Toshio Fujita, Classical and Three-Dimensional QSAR in Agrochemistry. Developed from a symposium sponsored by the Division of Agrochemicals at the 208th National Meeting of the American Chemical Society, Washington, DC, August 21-25, 1994, in ACS Symposium Series 606, American Chemical Society, Washington, DC, 1995. 

This chapter is dedicated to Dr. Toshio Fujita, pioneer, mentor, and friend. 

While bioisosterism had been comprehensively treated in several printed reviews dealing with common replacements used in analogue design, computer databases allowing (sub)structure searches were slow to appear. Toshio Fujita was the first to tackle this problem and, in the early 1990s, developed EMIL (Example-Mediated Innovation for Lead Evolution), an expert system built around a knowledge base of thousands of consecutive structural modification patterns for several drug and pesticide classes described in the literature [12, 13]. ... 

Toshio Fujita Keiichiro Nishimura Zhi-Ming Cheng, ... 

A special award recognizing Toshio Fujita s contribution to biological, computational, and synthetic chemistry was presented to him at the 1992 conference by the Division of Agrochemicals of the American Chemical Society. The award was presented at a session held in Fujita s honor entitled Evolving Approaches to Pesticide Discovery . 

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