From Sophora flavescens

Isomatrine was isolated from Sophora flavescens Ait. (79,208). There are absorption bands of a lactam group at 1620 cm and a rrani-quinolizidine at 2740, 2760, and 2780 cm in the IR spectrum. Heating of isomatrine (29) in aqueous solution with Pt02/H2 results in epimerization, and a mixture of matrine... 

Dehydrosophoramine was isolated from Sophora flavescens Ait. (225). The IR spectrum of the base is characterized by the presence of an a-pyridone... 

Kuroyanagi, M. et al.. Antibacterial and antiandrogen flavonoids from Sophora flavescens. Journal of Natural Products, 62, 1595, 1999. 

Matsuda, K., Kimura, M., Komai, K., and Hamada, M. 1989. Nematicidal activities of (-)-N-methylcytisine and (-)-anagyrine from Sophora flavescens against Pine wood nematodes. Agric. Biol. Chem. 53, 2287-2288... 

Cai et al. first used a chloroform-0.07 M sodium phosphate buffer (pH 6.4-6.5) solvent system for the separation of matrine and oxymatrine from Sophora flavescens, atropine, scopolamine, and hyoscyamine from Datura mete L. by HSCCC. Cooper et al. successfully used chloroform-0.2 M potassium phosphate buffer with an optimum pH value of each at 5.0, 5.6, 6.0, and 7.4 for the separation of pyrrolizidine alkaloids from various sources of Senecio douglasii var. longilobus, Trichodesma incanum, Symphytum spp. and Amsinckia tessellata, respectively. 

Fig. 12 Flavonoids for test of estrogen receptor binding from Sophora flavescens...

In addition to measuring the antioxidant effects of prenylated flavonoids from Sophora flavescens by using in vitro l,l-diphenyl-2-picrylhydrazyl (DPPH), 2,2/-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), per-oxynitrite (ONOCT), and total reactive oxygen species (ROS) assays, the examination of the inhibition of tert-butylhydroperoxide (f-BIIP)-induced intracellular ROS generation and f-BHP-induced activation of nuclear factor-kB (NF-/cB) was also added as a further examination of kuraridinol (9),... 

Fig. 29 Prenylated flavonoids with tyrosinase inhibitory activity from Sophora flavescens and kojic acid (a control) (126)...

Fig. 30 Tyrosine inhibitory prenylated flavonoids from Sophora flavescens and kojic acid (126) as a control of tyrosine inhibition...

In previous study, the prenylated flavonoids kuraridin (8), sophoraflavanone G (10), kurarinone (13), and kushenol F (127) from Sophora flavescens showed tyrosinase inhibitor activity. Interestingly, based on the level of these... 

Fig. 36 Inhibitory effects of trifolirhizin (2), kurarinol (3), and kuraridinol (9) from Sophora flavescens on tyrosinase and melanin synthesis...

Fig. 37 Inhibitory prenylated flavonoids from Sophora flavescens against aldose reductase and generation of advanced glycation endproducts...

Table 11 Prenylated flavonoids from Sophora flavescens for the inhibition of mast cell degranulation...

Isolation and Identification of an Estrogenically Active Component from Sophora flavescens Ait... 

Choi, S.U.N., KH. Kim, E.J. Choi, et al. 1999. P-glycoprotein (Pgp) does not affect the cytotoxicity of flavonoids from Sophora flavescens, which also have no effects on Pgp action. Anticancer Res. 19(3A) 2035-2040. 

Funaya, N., Haglnaka, J. (2012). Matrlne- and oxymatrlne-lmprinted monodisperse polymers prepared by precipitation polymerization and their applications for the selective extraction of matrine-lype alkaloids from Sophora flavescens Alton, J ClTrgmaWgn 1248, 18-23. 

Similarly, Sugiyama and coworkers recently used broad substrate-speciflc prenyltransferases, NphB, SCO7190, and NovQ, from Streptomyces and two plant genes, N8DT and G6DT, from Sophora flavescens to generate 624 transgenic... 

Terada M, Sano M, Ishii Al, Kino H et al. 1982 Studies on chemotherapy of parasitic helminths (4). Effects of alkaloids from Sophora flavescens on the motility of parasitic helminths and isolated host tissues. Folia Pharmacol Japon 79 105-111... 

Prenylated (iso)flavonoids are relatively common antimicrobial compounds in plants (e.g. in fruits of Osage orange [Madura pomif-era and roots of white lupin) (see wighteone in Fig. 6). The first characterization of a plant fla-vonoid PT at the molecular level was recently reported naringenin 8-prenyltransferase from Sophora flavescens is related to the homoge-ntisate PTs involved in the formation of toco-pherols and tocotrienols [116]. 

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