Freely and Commercially Available Tools for the Study of P450 in Brain

4 Freely and Commercially Available Tools for the Study of P450 in Brain 

In addition to those mentioned already, the number and type of commercially available tools to aid in the identification and analysis of cytochrome P450 in the brain and elsewhere has exploded in recent years. O Table 3-1 collates some of the available materials as of early 2004, and this will undoubtedly expand in the years to come. Several companies now sell cytochrome P450s themselves in several expression formats, purified for example or supplied in membrane preparations along with NADPH reductase. 

Cytochromes P450 with xenobiotic function in human brain (Amruthesh et al., 1992 Degtyarenko and Fabian, 1996 Nelson, 1998 Chang and Kam, 1999 Omiecinski et al., 1999 Nebert and Russell, 2002 Stoffel-Wagner, 2003) 

WB shows CYP7A/induction in arachnoid, dura mater, choroid plexus, pineal gland, and pituitary of rat brain by //-naphthoflavone (Morse et al., 1998). 

No CYPlAl protein or activity in purified rat brain mitochondria (Morse et al., 1998). 

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