Nanotechnological formulation

To introduce micronization or nanotechnology to maximize drug dissolution from the formulation... 

In summary, the formation of various gel-type materials using different synthetic routes has been described in this contribution. The advantages of the miniemulsion technique include its versatility in terms of the materials used and the reaction conditions, simplicity of formulation, and high reproducibility. The miniemulsion technique allows one to produce nanoparticles with controlled size and surface properties, which are very important parameters for further application in the area of nanotechnology. 

Not withstanding the use of nanoparticles for intravenous and topical applications, improvement in oral bioavailability is one of the most important contributions attained through nanotechnology. Molecules that are poorly water soluble may be poorly absorbed because of a lack of sufficient concentrations of solubilized drug. Formulations that are amorphous can overcome this by supersaturation of the dissolution medium allowing for greater absorption of the delivered dose. However, stability problems are significant for... 

Pharmaceutical Properties of Nanotechnological Formulations 22.2.2.1 Drug-Loading Capacity... 

The wide spectrum of self-assembly phenomena can be categorized in various ways. In this entry, we discuss the similarities and the differences between two- and three-dimensional systems. The last section of this entry describes recent and possible future applications of self-assembly processes, mainly related to advanced materials, environmental issues, biotechnology, and nanotechnology. Emulsions, microemulsions, and foams are examples of important and common applications in which self-assembly plays a key role. These have a wide variety of industry applications from cosmetics, foods, detergents, oil recovery, drug formulation/delivery, petroleum refining, and mining. As these are the subjects of other topics in this encyclopedia, they are not covered here. 

Huge advances have been made over the last 15 years in the research, development, application, commercialization and understanding of the mechanisms of action of nanoscale drug delivery systems. Many of these advances have had a spectacular impact on the prevention, diagnosis and treatment of a wide range of diseases. This is especially trae in the treatment of many cancers, and it is in the oncology field that the majority of the formulation advances have been made. Pharmaceutically, the most important nanotechnologies are exemplified and discussed below (see Table 39.10 for definitions and descriptions). 

In the future, nanotechnology is likely to benefit many areas of medicine such as sensors for use in the laboratory or clinic and within the human body, new drug formulations, and novel drug-delivery systems. The most important potential uses of nanotechnology in medicine include the early detection and treatment of disease. 

Ramsay EC, Dos Santos N, Dragowska WH, Laskin JJ, Bally MB. The formulation of lipid-based nanotechnologies for the delivery of fixed dose anficancer drug combinations. Curr Drug Deliv 2005 Oct 2(4) 341-351. 

We believe that the low viscosity of CO2, coupled with its excellent wetting properties, will enable whole new classes of thin-film coating operations that will at the same time be environmentally responsible. These are likely to be important, not just for microelectronics applications but also for biomedical and nanotechnology formulations. Even though there are still many technical and economic barriers to the total acceptance of these technologies, we believe that environmental pressures as well as technical requirements for pure component systems with high uniformity will over time help dry" C02-based processes play an increasingly important role in industrial environments. 

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