Forming Multivalent and Multicomponent Vaccines

Antigen Expression system Immunogenicity Protective challenge Reference [Pg.144]

Bacillus anthracis protective antigen Tobacco leaf No immunogenicity assays. - 86 [Pg.144]

Bovine herpes virus type 1 (BHV1) glycoprotein D (gDc) Tobacco leaf Sustained and specific humoral and cellular immune response in mice and cows when delivered once parenterally. Cows challenged with infectious dose of BHV1 exhibited milder symptoms over a shorter duration. 87 [Pg.144]

Enteropathogenic E. coli pilus subunit A (BfpA) Tobacco leaf Immunogenic when delivered orally in mice. Anti-BfpA in fecal matter. - 88 [Pg.144]

Enterotoxigenic E. coli B subunits of the heat labile toxin (LTB) Maize seed Elicited neutralizing antibodies. Immunogenic when administered orally. Serum and secretory immune responses in humans. Partially protective in mouse gut fluid assay. 27-29, 89, unpublished data [Pg.144]

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