Vaccine multicomponent

The single-component bacterial vaccines are listed in Table 15.1. For each vaccine, notes are provided of the basic material fkm which the vaccine is made, the salient production processes and tests for potency and for safety. The multicomponent vaccines that are made by blending together two or more of the single component vaccines are required to meet the potency and safety requirements for each of the single components that they contain. The best known of the combined bacterial vaccines is the adsorbed diphtheria, tetanus and pertussis vaccine (DTPerWac/Ads) that is used to immunize infants, and the adsorbed diphtheria and tetanus vaccine (DTWac/Ads) that is used to reinforce the immunity of school entrants. 

Fig. 4 (a) Recent OVA-GLP multicomponent TACA vaccine incorporating the requisite elements to raise both humoral and cytotoxic immunity, (b) Hexadecavalent dendri-RAFT structures proposed by Renaudet and colleagues... 

Worldwide, B strains continue to cause severe meningococcal disease. Three doses of a multicomponent meningococcal serogroup B vaccine (4CMenB) were assessed for safety and tolerability in a Chilean study. Local and systemic AEs were similar after each vaccination dose. Booster doses did not result in an increase in local or systemic reactions [90 ]. 

There have been specific interest and debate into the new multicomponent MenB vaccine (4CMenB). Naturally, the vaccine s impact on routine immunisation has been a question of interest. A phase lib, multicenter, open-label, parallel-group, randomised control study cf infants enrolled at age Imonths (n=1885) was randomised into four groups 4CMenB at 2, 4 and... 

Santolaya ME, O Ryan ML, Valenzuela MT, Prado V, Vergara R, Munoz A, et al. Immrmogenidty and tolerabUity of a multicomponent meningococcal serogroup B (4CMenB) vaccine in healthy adolescents in ChUe a phase 2b/3 randomised, observer-blind, placebo-controUed study. Lancet 2012 379(9816) 617-24. 

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