Formic acid amides

Formic acid amide, MA -dimethyl 12.1 Sulfone, dipropyl 11.3... 

Formic acid amide, N-ethyl 10.8 Succinic acid anhydride 16.1... 

Formic acid amide, N-methyl 15.4 Tetraethylene glycol 16.5... 

FORMIC ACID, AMIDE (75-12-7) Combustible liquid (flash point 310°F/154°C oc). Reacts slowly with water, forming hydrocyanic acid and ammonium formate. Incompatible with strong acids, alkali metal acetates, ammonia, cellulose acetate, cresols, isocyanates, metal chlorides, oleum, phenols, polyvinyl alcohol. 

AI3-15357 Amid kyseliny mravenci Carbamaldehyde CCRIS 6240 EINECS 200-842-0 Formamide Formic acid, amide Formimidic acid HSDB 88 Methanamide Methanoic xid, amide NSC 748. Solvent, softener, intermediate in organic synthesis. Liquid mp = 2.55 bp = 220 d = 1.1334 soluble in H2O, organic solvents LDso (rat orl) = 6570 mg/kg. BASF Corp. Fluka Penta Mfg. Sigma-Aldrich Fine Chem. 

Beilstein Handbook Reference) AI3-26076 BRN 1098352 EINECS 204-624-6 EK 7011 Formamide, N-methyl- Formic acid amide, N-methyl- HSDB 100 Methylformamide Monomethylformamide N-Methyl formamide NSC 3051 X 188,... 

Synonyms N,N-Dimethylformamide N,N-Dimethylmethanamide DMF DMFA Formic acid, amide, N,N-dimethyl-N-Formyldimethylamine Classification Amide Empirical C3H7NO Formula CHCON(CH3)2 Properties Water-wh. clear liq. fishy unpleasant odor a dipolar aprotic solv. sol. in water misc. with alcohol, ether, acetone, benzene, most org. soivs. Insol. in aliphatic hydrocarbons m.w. 

Formic acid, amide, N,N-dimethyl-. See Dimethyl formamide... 

The uses of dimethyl acetamide are very similar to those for dimethylform amide [68-12-2] (see FoRMiC ACId). DMAC is employed most often where higher temperatures are needed for solution of resins or activation of chemical reactions. 

Formic acid exhibits many of the typical chemical properties of the aHphatic carboxyHc acids, eg, esterification and amidation, but, as is common for the first member of an homologous series, there are distinctive differences in properties between formic acid and its higher homologues. The smaller inductive effect of hydrogen in comparison to an alkyl group leads, for example, to formic acid = 3.74) being a considerably stronger acid than acetic acid... 

If one amino group in o-phenylenediamine is converted to an amide group by formic acid, the intermediate benzimidazole is formed. This reaction, conducted with a wide range of reactants, produces resins (polybenzimidazoles) used as high-temperature adhesives for laminates in the aerospace industry. Heat insulation is made by including tiny bubbles of silica and all... 

When o-aminobenzophenone is heated with formamide in the presence of formic acid at 150°C for 20 min, a quantitative yield of 4-phenylquinazoline is obtained. In the absence of formic acid longer heating is necessary. Although this reaction does not proceed with o-acylamidobenzophenones, its extension to other o-acylanilines with aliphatic amides may prove fruitful. 

C. MEDINA. The crude methylenedi(nitro-formamide) is pressed dry on the filter, stirred into lOSml of formic acid, and the paste allowed to stand overnight. The next day the soln is filtered thru an acid-proof flit, the formic acid and w removed by codistn with xylene, and the crude MEDINA, which seps as a sand, filtered and dried over paraffin and NaOH in a vacuum yield 80—100% based on methylene diform-amide, mp 98—103°. The crude MEDINA is recrystd from 2-nitropropane or et chloride iso-Pr ale 9 1, mp 104-059 (Ref 11, p 54). This prepn is also covered in Ref 20... 

The reaction proceeds via die hydrolysis of nitrile groups to an amide. The amides may also be A-formyl amines, which react with acid groups whereby volatile formic acid is shipped10 ... 

Carboxylic esters can be treated with ketones to give p-diketones in a reaction that is essentially the same as 10-118. The reaction is so similar that it is sometimes also called the Claisen condensation, though this usage is unfortunate. A fairly strong base, such as sodium amide or sodium hydride, is required. Yields can be increased by the catalytic addition of crown ethers. Esters of formic acid (R H) give P-keto aldehydes. Ethyl carbonate gives P-keto esters. 

Aqueous HCI solutions hydrolyze the P-N bond to give the amine hydrochloride and R2P-OH, which then disproportionates and is oxidized to diphenylphosphinic acid. A free phosphinous amide anion, with the countercation complexed by a crown ether, has been shown to be hydrolyzed and oxidized to the corresponding phosphinite with unusual ease [119]. Formic acid in toluene can be utilized for converting P,P-disubstituted phosphinous amides into their respective phosphane oxides [30]. 

Formic acid Itself gives amide (50) which is eyclised to (49) in good yield with POCl. ... 

Acyl groups are common in bacterial polysaccharides. The parent acids are fatty acids, hydroxy acids, and amino acids. The simplest acid, formic acid, has only been found as the amide. The occurrence of O-formyl groups had been reported, but proved to be incorrect. A-Formyl groups have been found in different polysaccharides for example, in the 0-specific side-chains of the LPS from Yersinia enlerocolitica 0 9, which are composed of 4,6-dideoxy-4-formamido-D-mannopyranosyl residues. The formyl group can assume two main conformations, s-cis (41) and s-trans (42), which are... 

Ethonam (99), an imidazole derivative with a very different substitution pattern, is also reported to possess antifungal activity. To prepare it, alkylation of aminotetralin 94 with methylchloro-acetate gives the glycine derivative 95. Heating with formic acid then affords the amide 96 this compound is then reacted with ethyl formate to yield hydroxymethylene ester 97. Reaction with isothio-cyanic acid gives the imidazole-2-thiol 98. (The... 

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