Forkhead transcription factor

FOXOS, protein kinase B-regulated Forkhead transcription factor... 

Fontenot JD. Rasmussen JP. Williams LM, Dooley JL. Farr AG. Rudensky AY Regulatory T cell lineage specification by the forkhead transcription factor Foxp3. Immunity 2005 22 329-341. 

Motta, M.C., Divecha, N., Lemieux, M., Kamel, C., Chen, D., Gu, W., Bultsma, Y, McBurney M. and Guarente, L. (2004) Mammalian SIRTl represses forkhead transcription factors. Cell, 116,... 

Kau, T. R., Schroeder, F., Ramaswamy, S., et al. (2003) A chemical genetic screen identifies inhibitors of regulated nuclear export of a forkhead transcription factor in PTEN deficient tumor cells. Cancer Cell 4, 463-467. 

Kawano, T., Morioka, M., Yano, S., Hamada, J., Ushio, Y., Miyamoto, E., and Fukunaga, K. (2002). Decreased Akt activity is associated with activation of Forkhead transcription factor after transient forebrain ischemia in gerbil hippocampus. J. Cereb. Blood Flow Metab. 22, 926-934. 

Kops GJ, Dansen TB, Polderman PE, Saarloos I, Wirtz KW, Coffer PJ, Huang TT, Bos JL, Medema RH, Burgering BM (2002) Forkhead transcription factor FOX03a pro-... 

Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME (1999) Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 96(6) 857-868... 

Kops GJ, Medema RH, Glassford J, Essers MA, Dijkers PF, Coffer PJ, Lam EW, Burgering BM (2002) Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. Mol Cell Biol 22(7) 2025-2036... 

Medema RH, Kops GJ, Bos JL, Burgering BM (2000) AFX-like forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kipl. Nature 404(6779) 782-787. doi 10.1038/35008115... 

STAT see Section 12.2.2 PLC see Chapter 6 PI3-K see Section 6.6.1 Ras see Chapter 9 MAPK, Cdc42/ JNK see Chapter 10 PTP protein tyrosine phosphatase FKHR Forkhead transcription factor S6-K ribosomal protein S6 kinase GSK-3 gylcogen synthase kinase 3. After Schlessinger (2000). 

Forkhead-associated domains (FHA domains) were originally identified as conserved sequence elements within a subset of forkhead transcription factors and were subsequently found, e. g., in other transcription factors, in protein kinases, protein phosphatases, and kinesin motors (review Durocher and Jackson, 2002). FHA domains comprise up to 140 amino acids, exhibit binding specificity toward phosphothreonine residues, and efficiently discriminate against phosphoserine residues. 

The mode of action of Smad 4 clearly differs from that of the other members of the Smad family. Smad 4 binds to phosphorylated R-Smads and forms trimeric complexes composed of two R-Smad molecules and one Smad 4 molecule. These complexes translocate to the nucleus, where they bind to related DNA elements and activate the transcription of target genes. The mechanism of transcription regulation by Smads is complex and includes both positive and negative influences. Generally, Smad-dependent regulation of transcription requires the interaction with other transcription factors, such as members of the FoxH 1 family of forkhead transcription factors, the Vitamin D receptor and the c-Jun transcription factor, among others (review Attisano et al., 2001). Futhermore, Smads can interact with coactivators and corepressors of transcription and thereby recruit, e. g., histone acetylase activity or histone deacetylase activity to chromatin. 

Nakae, J., Kitamura, T., Silver, D. L., and Accili, D. (2001) The forkhead transcription factor FoxOl (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. 

Nude mice (nu/nu) have a defect in expression of forkhead transcription factor FoxNl that results in impairment of T cell development (Balciunaite et al., 2002). As shown in Table 10.1-4, nu/nu mice show increased susceptibility to a number of infectious organisms and tumors and decreased effectiveness... 

Brunet, A., Park, J., Tran, H., Hu, L. S., Hemmings, B. A., and Greenberg, M. E. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRLl (FOX03a). Mol Cell Biol 21 (2001) 952-965. 

Daitoku, H., Yamagata, K., Matsuzaki, H., Hatta, M., and Fukamizu, A. Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR. Diabetes 52 (2003) 642-649. 

Obsil, T., Ghirlando, R., Anderson, D. E., Hickman, A. B., and Dyda, F. Two 14-3-3 binding motifs are required for stable association of Forkhead transcription factor FOX04 with 14-3-3 proteins and inhibition of DNA binding. Biochemistry 42 (2003) 15264-15272. 

Obsilova, V., Vecer, J., Herman, P., Pabianova, A., Sulc, M., Teisinger, J., Boura, E., and Obsil, T. 14-3-3 Protein interacts with nuclear localization sequence of forkhead transcription factor Fox04. Biochemistry 44 (2005) 11608-11617. 

Woifrum, C., Besser, D., Luca, E., and Stoffel, M. Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/ cytosolic localization. Proc Natl Acad Sci U S A 100 (2003) 11624-11629. 

Nakagawa S, Gisselbrecht SS, Rogers JM, Haiti D, Bulyk M. DNA-binding specificity Changes in the evolution of forkhead transcription factors. Proc Natl Acad Sci (7SA 2013 110(30) 12349-54. 

Takahashi Y, Daitoku H, Hirota K, Tamiya HJ, Yokoyama A, Kako K, Nagashima Y, Nakamura A, Shimada T, Watanabe S, Yamagata K, Yasuda K, Ishii N, Fukamizu A. Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16. Cell Metab. 2011 13 505-16. 

FORKHEAD TRANSCRIPTION FACTORS Edited by Kenneth Maiese... 

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