Forensic science, capillary electrophoresis

Smyth WE, Brooks P. 2004. A critical evaluation of high performance liquid chromatography ionization-mass spectrometry and capillary electrophoresis-electrospray-mass spectrometry for the detection and determination of small molecules of significance in clinical and forensic science. Electrophoresis 25 1413. 

Fig. 3. Processing scheme. Reprinted with permission from Warren et al. [46]. Copyright (1999) Forensic Science Society. CE, capillary electrophoresis GC, gas chromatography TEA, thermal energy analyser IC,...

During the last decade, capillary electrophoresis (CE) has developed into a widely applied method for the analysis of pharmaceuticals (both for the evaluation of pharmaceutical formulations and metabolites). These applications established the basis for introducing CE into the forensic held also. Today, capillary electrophoresis can be applied to a number of analytical problems in forensic science, including the analysis of gunshot residues, explosives, inks, dusts, soils, and, of course, illicit drugs, diverse toxicants, DNA hngerprinting, protein analysis, and so forth (for reviews, see Refs. 1 and 2). 

Within the last 25 years, capillary electrophoresis (CE) has developed as a high-resolution analytical technique that has been apphed to all analytical helds including chemical, pharmaceutical, biomedical, forensic, environmental analysis, and food sciences. Based on the number of publications, drugs are actually the preferred analytes in CE. While they served as model compounds for the investigation of specific aspects in some studies, CE has been used to solve real pharmaceutical problems in the majority of applications. 

See also Capillary Electrophoresis Clinical Applications. Forensic Sciences DNA Profiling. Lab-on-a-Chip Technologies. Mass Spectrometry Polymerase Chain Reaction Products. Nucleic Acids Chromatographic and Electrophoretic Methods. 

B. R. McCord (ed.) Paper Symposium Capillary Electrophoresis in Forensic Science, Electrophoresis 19(1998) 3-124. 

Source Northrop, D. "Forensic Applications of High-Performance liquid Chromatography and Capillary Electrophoresis," in R. Saferstein, ed.. Forensic Science Handbook, (2d) ed., Vol. 1. Upper Saddle River, NJ Prentice Hall, 2002. 

Tagliato, F., et al. "Capillary Electrophoresis Principles and Applications in Illicit Drug Analysis." Forensic Science International, T11996,211-229. 

Sources (1) Liau, A. S., et al. "Optimization of a simple method for the chiral separation of methamphetamine and related compounds in clandestine tablets and urine samples by beta-cyclodextrine modified capillary electrophoresis a complementary method to GC-MS." Forensic Science International, 134 2003,17-24. (2) Cheng, W.-C., et al. "Enantiomeric Separation of Methamphetamine and Related Analogs by Capillary Zone Electrophoresis Intelligence Study in Routine Methamphetamine Seizures." Journal of Forensic Sciences, 47 2002,1248-1252. (3) Al-Dirbashi, O., et al. "Achiral and Chiral Quantification of Methamphetamine and Amphetamine in Urine by Semi-micro Column High Performance Liquid Chromatography and Fluorescence Detection." Journal of Forensic Sciences, 45 2000,708-714. 

Frost, M., and H. Kfihler. "Analysis of Lysergic Acid Diethylamide Comparison of Capillary Electrophoresis with Laser-indued Fluorescence (CE-LIF) with Conventional Techniques." Forensic Science International, 92 1998, 213-218. 

D. "Gunshot Residue Analysis by Micellar Electrokinetic Capillary Electrophoresis Assessment for ApplicaHon to Casework" (Parts 1 and 2). Journal cf Forensic Sciences 46 (2001), 549-572. 

A., eta .. Sampling Protocols for the Detection of Smokeless Powder Residues Using Capillary Electrophoresis, Journal of Forensic Sciences 43 (1998). 119-124. Copyright 1998 ASTM International. 

Casamento, S., et al. "Optimization of the Separation of Organic Erqrlosives by Capillary Electrophoresis with Artificial Neural Networks." Journal of Forensic Sciences 48 (2003), 1075-1083. 

Vogt, C., et al. "Investigation of Bedl Point Pen Inks by Capillary Electrophoresis (CE) with UV/Vis Absorbance and Laser Induced Fluorescence Detection and Particle Induced X-Ray Emission (FIXE)." Journal of Forensic Sciences 44 (1999), 819-831. 

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