Foreign body giant cells

Slavik, J. and Smetana, K. (1997). Intracellular pH of macrophages and foreign body giant cells colonising an implant surface, J. Fluores., 7, 203S-205S. 

DC-STAMP DC STAMP Osteopetrosis with inactive mononuclear osteoclasts Failure of foreign body giant cell formation... 

Yagi, M., Miyamoto, T., Sawatani, Y., Iwamoto, K., Hosogane, N., Fnjita, N., Morita, K., Ninomiya, K., Suzuki, T., Miyamoto, K., Oike, Y., Takeya, M., Toyama, Y., and Suda, T. (2005) DC-STAMP is Essential for Cell-Cell Fusion in Osteoclasts and Foreign Body Giant Cells. Journal of Experimental Medicine 202, 345-351. 

Macrophage and its Fused Foreign-Body Giant Cell. 103... 

Foreign Body Giant Cell Formation In Vitro... 

Lambert R A. The production of foreign body giant cells in vitro. Journal of Experimental Medicine 1912, 15, 510-515. 

Papadimitriou JM, Robertson TA, Walters MN. An analysis of the phagocytic potential of multinucleate foreign body giant cells. American Journal of Pathology 1975, 78, 343-358. 

Kao WJ, McNally AK, Hiltner A, Anderson JM. Role for interleukin4 in foreign-body giant cell formation on a poly(etherurethane urea) in vivo. Journal of Biomedical Materials Research 1995, 29, 1267-1275. 

Yagi M, Takeshi M, Yumi S, Katsuya I, Naobumi H. DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells. Journal of Experimental Medicine 2005, 202, 345-351. 

Figure 3.1 H E section showing foreign body giant cells obtained 28 days after subcutaneous implantation of aporous polyvinyl alcohol implant in arat. Reprinted with permission from Ref. 10. Copyright 2004 John Wiley Sons. (See the color version of this figure in Color Plates section.)...

Tsai AT, Rice J, Scatena M, Liaw L, Ratner BD, Giachelli CM. The role of osteopontin in foreign body giant cell formation. Biomaterials 2005, 26, 5835-5843. 

Jenney CR, Anderson JM (1999) Effects of surface-coupled polyethylene oxide in human macrophage adhesion and foreign body giant cell formation in vitro. J Biomed Mater Res... 

Foreign body giant cell granulomas were first reported after liquid silicone injection in 1965 (14) and are usually observed near siUcone-injected areas (15). There have been many reports of cysts and granulomatous reactions to silicone at application sites and distal sites after hematogenous or lymphatic migration (15-17). 

The mechanism of action of talc in pleurodesis has not been fully elucidated, although it is thought to stimulate a typical local inflammatory response, with reduced fibrinolytic activity, mesothelial cell injury, and fibroblast proliferation. Pneumonitis or respiratory failure can be secondary to downstream inflammatory mediators from more proximal talc injury (7). This acute-phase inflammatory response is dose-related (8,9) and is inhibited by glucocorticoids (10). Talc may also have an adhesion stimulating quality, since empyema alone stimulates a typical inflammatory response but does not lead to pleurodesis (11). In fact, talc stimulates intercellular adhesion molecule-1 in mesothelial cells (12). The mechanism of chronic fibrosis may involve continuous fibroblast activation by foreign body giant cell released mediators or macrophages. 

M. Shen, 1. Garda, R.V. Maier, T.A. Horbett, Effects of adsorbed proteins and surface chemistry on foreign body giant cell formation, tumor necrosis factor alpha release and procoagulant activity of monocytes, J. Biomed. Mater. Res. A 70 (2004) 533-541. 

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