Follicle-stimulating hormone reproduction

Hillier, S. 1994. Current concepts of the role of follicle stimulating hormone and luteinizing hormone in follicu-logenesis. Human Reproduction 9(2), 188-191. 

FIGURE 8.4 The Bronson model of priming pheromone actions in rodents. Chemical signaling between males and females constitutes a feedback mechanism that results in accelerated maturation and reproduction. This, in turn, permits the mice to adjust their reproduction and population size quickly to respond to environmental conditions such as sudden food abundance at harvest time. FSH, follicle-stimulating hormone LH, luteinizing hormone PRL, prolactin. Stimulation and inhibition are marked by - - and —, respectively. (From Bronson and Coquelin, 1980.)... 

Frydman R, Howies CM, Truong F. A double-blind, randomized study to compare recombinant human follicle stimulating hormone (FSH Gonal-F) with highly purified urinary FSH (Metrodin) HP) in women undergoing assisted reproductive techniques including intracytoplasmic sperm injection. The French Multicentre Trialists. Hum Reprod 2000 15(3) 520-5. 

Figure 33.2. Endocrine feedback loops of the mammalian hypothalamic-pituitary-gonadal (HPG) axis. (Adapted from La Barbera A. R. Differentiation and function of the female reproductive system. In Boekelheide, K., Chapin, R. E., Hoyer, P. B., and Harris, C. (Eds.). Comprehensive Toxicology, Vol. 10, Reproductive and Endocrine Toxicology, Elsevier, New York, 1997, pp. 255-272 and Creasy, D. M., and Foster, P. M. D. Male reproductive system. In Haschek, W. M., Rousseaux, C. G. and Wallig, M. A. (Eds.). Handbook of Toxicologic Pathology, 2nd ed., Academic Press, San Diego, 2002,pp. 785-846. E2, estradiol T, testosterone, DHT, dihydrotestosterone, FSH, follicle stimulating hormone LH, luteinizing hormone.

Figure 33.3. The female reproductive cycle. FSH, follicle stimulating hormone GnRH, gonadotropin-releasing hormone LH, luteinizing hormone. (Reproduced with permission from Thomas, M. J., and Thomas, J. A. Toxic responses of the reproductive system. In Klaassen, C. D. (Ed.). Casarett and Doull s Toxicology, 6th ed. McGraw-Hill, New York, 2001, pp. 673-709.

B11. Buyalos, R. P., Daneshmand, S., and Brzechffa, P. R., Basal estradiol and follicle-stimulating hormone predict fecundity in women of advanced reproductive age undergoing ovulation induction therapy. Fertil. Steril. 68, 272-277 (1997). 

Q2 Explain the profile of gonadotropic hormones activity, i.e. luteinizing hormone (LH) and follicle-stimulating hormone (FSH), in a typical 28-day female reproductive cycle... 

Follicle-stimulating hormone FSH Ovaries, testes Growth of reproductive system... 

Azizi et al. (1995) investigated changes in serum concentrations of reproductive hormones and sperm counts in men who had been exposed to sulfur mustard during wartime. In 16 individuals, serum free and total testosterone and dehydroepiandrosterone were markedly decreased in the first five weeks after exposure but levels returned to normal by 12 weeks. In 28 of 42 men evaluated one to three years after exposure, sperm counts were less than 30 million ceUs/mL and follicle-stimulating hormone was increased compared to controls having sperm counts above 60 million cells/mL. Testicular biopsy of the test subjects revealed partial or complete arrest of spermatogenesis. 

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