Folate/folic acid

Folate coenzymes, 803, 804. See also Folic acid Folate receptors 805 3-Fold axis 333 Folding patterns... 

Folic Acid (folate). Chemically, folic acid is a pteryl-glutamic acid. The several forms that occur in nature depend on the numbers of glutamic acid units and methyl groups in the molecules. Because of its usual low concentration, folic acid is generally determined in food materials by the microbiological assay with lactobacillus casei and measured turbidimetrically or titrimetrically. Deficiency of this vitamin could result in... 

Category Antimetabolite Antineoplastic Folate analogue Half-life Terminal up to 198 Hours Clinically important, potentially hazardous interactions with folic acid/folates, L-methylfolate... 

Frenkel EP, Yardley DA. Clinical and laboratory features and sequelae of deficiency of folic acid (folate) and vitamin Bj (cobalamin) in pregnancy and gynecology. Hematol Oncol Clin North Am 2000 14(5) 1079-100. 

The vitamin folic acid (folate) is converted to its biologically active form by two successive reductions of the pteridine ring. Both reactions are catalyzed by dihydrofolate reductase. 

Folic acid (folate) Tetrahydrofolate (THF) One-carbon transfer Megaloblastic anemia... 

Tetrahydrofolate (THF) is the coenzyme used by enzymes that catalyze reactions that transfer a group containing a single carbon to their substrates. The one-carbon group can be a methyl group (CH3), a methylene group (CH2), or a formyl group (HC=0). Tetrahydrofolate is produced by the reduction of two double bonds of folic acid (folate), its precursor vitamin. Bacteria can synthesize folate, but mammals cannot. 

Marienglas (Gips) foliation Folierung folic acid (folate)/ pteroylglutamic acid... 

Folic acid (folate) is found in green leafy vegetables and is involved in one-carbon metabolism. Folate supplements are vital during pregnancy. Groups of women who are prescribed folic acid show a significant decrease in the incidence of neural tube defects in their newborns (5b). 

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